Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
17: shared signals

First condition

Second condition

Comparison

Autism Spectrum DisorderandCrohn's Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

32: Autism Spectrum Disorder references
25: Crohn's Disease references
0: shared references

Metals elevated or accumulated

6 shared

Shared

Lead Mercury Cadmium Copper Nickel Arsenic

Only in Autism Spectrum Disorder

None indexed

Only in Crohn's Disease

Iron TissueCobalt MucosalIron Mucosal

Metals depleted or redistributed

3 shared

Shared

Zinc Glutathione (GSH)Selenium

Only in Autism Spectrum Disorder

Iron

Only in Crohn's Disease

Zinc LuminalIron LuminalManganese LuminalCopper LuminalManganese

Taxa enriched

0 shared

Shared

None indexed

Only in Autism Spectrum Disorder

Bacteroides Parabacteroides ClostridiumEubacterium CoprostanoligenesDesulfovibrio

Only in Crohn's Disease

Escherichia coli Fusobacterium nucleatum Enterococcus Ruminococcus gnavus Bacteroides fragilis Candida albicans Collinsella Debaryomyces Enterobacteriaceae

Taxa depleted

3 shared

Host response elevated

4 shared

Shared

Calprotectin (S100A8/A9)Lactoferrin Hepcidin Lipocalin-2

Only in Autism Spectrum Disorder

Transferrin TNF-alpha (Tumor Necrosis Factor Alpha)IL 1IL 6IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Only in Crohn's Disease

Pro Inflammatory CytokinesDUOX2Ceruloplasmin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Autism Spectrum Disorder

SulfateZinc IL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Only in Crohn's Disease

Anti Inflammatory CytokinesAlpha Defensins

Ecological state

0 shared

Shared

None indexed

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Only in Crohn's Disease

Barrier DysfunctionLeaky GutHypoxia BiofilmSCFA DepletionBile Acid DysmetabolismTryptophan DepletionFermentative Metabolism FerroptosisButyrate CollapseNOD2 Paneth Cell Defect

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Autism Spectrum Disorder

Beta-GlucuronidaseALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production

Only in Crohn's Disease

Siderophores Zinc-MetalloproteaseIron Dependent HydrogenaseCobalt Dependent EnzymesCopper Resistance DeterminantsMucin Degrading EnzymesSiderophores EnterobactinSiderophores YersiniabactinSiderophores AerobactinZinc Metalloprotease BFTFimH AdhesinOuter Membrane VesiclesNickel-Urease