Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

13%: weighted overlap
10: shared signals

First condition

Second condition

Comparison

Anxiety DisordersandAutism Spectrum Disorder

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

12: Anxiety Disorders references
32: Autism Spectrum Disorder references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Copper

Only in Anxiety Disorders

None indexed

Only in Autism Spectrum Disorder

Lead Mercury Cadmium Nickel Arsenic

Metals depleted or redistributed

2 shared

Taxa enriched

0 shared

Shared

None indexed

Only in Anxiety Disorders

Collinsella Escherichia coli Prevotellaceae

Only in Autism Spectrum Disorder

Bacteroides Parabacteroides ClostridiumEubacterium CoprostanoligenesDesulfovibrio

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Lactobacillus Lachnospiraceae

Only in Anxiety Disorders

Roseburia Blautia

Only in Autism Spectrum Disorder

Coprococcus

Host response elevated

2 shared

Shared

TNF-alpha (Tumor Necrosis Factor Alpha)IL 6

Only in Anxiety Disorders

Cortisol IL-1beta (Interleukin-1 Beta)CRP

Only in Autism Spectrum Disorder

Calprotectin (S100A8/A9)Lactoferrin Transferrin Hepcidin Lipocalin-2IL 1IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Host response depleted

0 shared

Shared

None indexed

Only in Anxiety Disorders

Butyrate Serotonin GABA (Gamma-Aminobutyric Acid)BDNF (Brain-Derived Neurotrophic Factor)

Only in Autism Spectrum Disorder

Glutathione (GSH)SulfateZinc IL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Ecological state

1 shared

Shared

Gut Barrier Dysfunction

Only in Anxiety Disorders

SCFA DepletionTryptophan Kynurenine ShuntingHPA Axis DysregulationVagal Signaling Disruption

Only in Autism Spectrum Disorder

Propionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Anxiety Disorders

Indoleamine 2 3 DioxygenaseTryptophanaseLPS Biosynthesis Enzymes

Only in Autism Spectrum Disorder

Beta-GlucuronidaseALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production