Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

23%: weighted overlap
22: shared signals

First condition

Second condition

Comparison

Type 2 DiabetesandCrohn's Disease

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

30: Type 2 Diabetes references
25: Crohn's Disease references
0: shared references

Metals elevated or accumulated

4 shared

Shared

Nickel Cadmium Arsenic Lead

Only in Type 2 Diabetes

Iron

Only in Crohn's Disease

Iron TissueCobalt MucosalMercuryIron MucosalCopper

Metals depleted or redistributed

3 shared

Shared

Zinc Glutathione (GSH)Manganese

Only in Type 2 Diabetes

Chromium Magnesium

Only in Crohn's Disease

Zinc LuminalIron LuminalManganese LuminalCopper LuminalSelenium

Taxa enriched

4 shared

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Akkermansia muciniphila Lachnospiraceae Roseburia

Only in Type 2 Diabetes

Bifidobacterium Ruminococcus Bacteroides fragilis Blautia

Only in Crohn's Disease

Eubacterium Lachnospiraceae (Family)Lactobacillus

Host response elevated

2 shared

Shared

Hepcidin Ceruloplasmin

Only in Type 2 Diabetes

LipopolysaccharideInflammatory CytokinesTNF-alpha (Tumor Necrosis Factor Alpha)IL 6Ferritin

Only in Crohn's Disease

Calprotectin (S100A8/A9)LactoferrinPro Inflammatory CytokinesDUOX2Lipocalin-2

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Type 2 Diabetes

ButyratePropionateAcetateBile AcidsZinc Chromium Manganese Magnesium

Only in Crohn's Disease

Anti Inflammatory CytokinesAlpha Defensins

Ecological state

2 shared

Shared

SCFA DepletionBile Acid Dysmetabolism

Only in Type 2 Diabetes

DysbiosisLPS ElevationImpaired Intestinal BarrierLipid PeroxidationReduced Microbial DiversityEndotoxemiaGut Barrier DisruptionBile Acid DysregulationIron Overload Oxidative StressFungal Overgrowth

Only in Crohn's Disease

Barrier DysfunctionLeaky GutHypoxia BiofilmTryptophan DepletionFermentative Metabolism FerroptosisButyrate CollapseNOD2 Paneth Cell Defect

Virulence and functional enzymes

2 shared

Shared

Siderophores Nickel-Urease

Only in Type 2 Diabetes

LipopolysaccharideCholine TMA LyaseBile Acid DehydrataseCarbohydrate Fermentation EnzymesLPS Biosynthesis EnzymesTMA Lyase CutC CutD

Only in Crohn's Disease

Zinc-MetalloproteaseIron Dependent HydrogenaseCobalt Dependent EnzymesCopper Resistance DeterminantsMucin Degrading EnzymesSiderophores EnterobactinSiderophores YersiniabactinSiderophores AerobactinZinc Metalloprotease BFTFimH AdhesinOuter Membrane Vesicles