Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

13%: weighted overlap
10: shared signals

First condition

Second condition

Comparison

Rheumatoid ArthritisandAutism Spectrum Disorder

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

7: Rheumatoid Arthritis references
32: Autism Spectrum Disorder references
0: shared references

Metals elevated or accumulated

4 shared

Metals depleted or redistributed

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

Vitamin D Nickel

Only in Autism Spectrum Disorder

Zinc Iron Glutathione (GSH)Selenium

Taxa enriched

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

Prevotella copri Escherichia coli Enterobacteriaceae Collinsella

Only in Autism Spectrum Disorder

Bacteroides Parabacteroides ClostridiumEubacterium CoprostanoligenesDesulfovibrio

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Lachnospiraceae Bifidobacterium

Only in Rheumatoid Arthritis

Bacteroides fragilis

Only in Autism Spectrum Disorder

Coprococcus Lactobacillus

Host response elevated

2 shared

Shared

Hepcidin Calprotectin (S100A8/A9)

Only in Rheumatoid Arthritis

Ceruloplasmin

Only in Autism Spectrum Disorder

Lactoferrin Transferrin Lipocalin-2 TNF-alpha (Tumor Necrosis Factor Alpha)IL 1IL 6IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Rheumatoid Arthritis

Vitamin D

Only in Autism Spectrum Disorder

SulfateZinc IL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Ecological state

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

Mucosal Origin AutoimmunityBarrier DysfunctionMolecular MimicryTh17 DominanceMetal VitD Bone AxisSoil Food Chain Exposure

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Rheumatoid Arthritis

MetalloproteinasesSiderophoresLPS Biosynthesis Enzymes

Only in Autism Spectrum Disorder

Beta-GlucuronidaseALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production