Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

10%: weighted overlap
8: shared signals

First condition

Second condition

Comparison

Irritable Bowel Syndrome (IBS)andGastroesophageal Reflux Disease (GERD)

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

7: Irritable Bowel Syndrome (IBS) references
16: Gastroesophageal Reflux Disease (GERD) references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Nickel

Only in Irritable Bowel Syndrome (IBS)

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 Metals

Metals depleted or redistributed

1 shared

Shared

Zinc

Only in Irritable Bowel Syndrome (IBS)

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Glutathione (GSH)Iron Magnesium Calcium

Taxa enriched

1 shared

Taxa depleted

2 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii

Only in Irritable Bowel Syndrome (IBS)

Lactobacillus

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Blautia Lachnospiraceae Akkermansia muciniphila Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Host response elevated

2 shared

Shared

Mast Cell MediatorsHistamine

Only in Irritable Bowel Syndrome (IBS)

TryptaseSerotonin

Only in Gastroesophageal Reflux Disease (GERD)

IL 6IL-8 (Interleukin-8 / CXCL8)NF KappaBTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T Cells

Host response depleted

0 shared

Shared

None indexed

Only in Irritable Bowel Syndrome (IBS)

Zinc Dependent Defensins

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic CellsGlutathione (GSH)

Ecological state

1 shared

Shared

SIBO

Only in Irritable Bowel Syndrome (IBS)

Nickel Allergic Contact MucositisMast Cell Nerve AxisVisceral HypersensitivityFermentative DysbiosisBarrier Dysfunction

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Irritable Bowel Syndrome (IBS)

TLR4 Nickel ActivationMast Cell Degranulation Mediators

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseLPS BiosynthesisArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal LipasesBeta-Glucuronidase