Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

8%: weighted overlap
6: shared signals

First condition

Second condition

Comparison

HypertensionandNecrotizing Enterocolitis

1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

14: Hypertension references
19: Necrotizing Enterocolitis references
1: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Hypertension

Lead Cadmium Nickel

Only in Necrotizing Enterocolitis

Iron

Metals depleted or redistributed

1 shared

Shared

Zinc

Only in Hypertension

Magnesium

Only in Necrotizing Enterocolitis

None indexed

Taxa enriched

1 shared

Shared

Klebsiella pneumoniae

Only in Hypertension

Enterobacteriaceae Streptococcus Prevotella Eggerthella Malassezia

Only in Necrotizing Enterocolitis

Klebsiella Escherichia coli Clostridium perfringens StaphylococcusClostridium Perfringens (Toxigenic)Sphingomonas Spp.Clostridium Spp. (Obligate Anaerobe Cluster)Bacteroides/Prevotella (Obligate Anaerobe Cluster)Staphylococcus epidermidis Enterococcus

Taxa depleted

1 shared

Host response elevated

2 shared

Shared

Il 6TNF-alpha (Tumor Necrosis Factor Alpha)

Only in Hypertension

HepcidinCrpIl 2r AlphaIl 18

Only in Necrotizing Enterocolitis

Calprotectin (S100A8/A9)Lactoferrin EndogenousPro Inflammatory CytokinesTLR4 ExpressionLPSIL-1beta (Interleukin-1 Beta)

Host response depleted

0 shared

Shared

None indexed

Only in Hypertension

Glutathione (GSH)Sod

Only in Necrotizing Enterocolitis

Zinc Defensins AcetateLactateSecretory IgA

Ecological state

0 shared

Shared

None indexed

Only in Hypertension

SCFA DepletionElevated Firmicutes Bacteroidetes RatioTMAO ElevationFungal DysbiosisLPS Driven EndotoxemiaBile Acid Disruption

Only in Necrotizing Enterocolitis

Proteobacteria Bloom 2 Weeks Pre DiagnosisVirome Convergence 10 Days Pre OnsetTLR4 Upregulation In Premature EpitheliumBifidobacterium Absence As PreconditionHMO Mediated Colonization ResistanceFeed Forward Barrier DestructionProteobacteria BloomTLR4 Feed Forward LoopVirome ConvergenceImmature BarrierParenteral Iron OverloadBiofilmBile Acid Accumulation ASBT UpregulationMuc2 Depletion Mucosal Barrier FailureObligate Anaerobe Mucosal InvasionGut Brain Axis NDI RiskAntibiotic Driven Richness Nadir Week4

Virulence and functional enzymes

1 shared

Shared

Siderophores

Only in Hypertension

TMA Lyases CutC CutDLPS Biosynthesis EnzymesFungal Lipases

Only in Necrotizing Enterocolitis

LPS BiosynthesisAlpha ToxinPerfringolysin OBiofilm Formation Enzymes