Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

10%: weighted overlap
8: shared signals

First condition

Second condition

Comparison

Gastroesophageal Reflux Disease (GERD)andIrritable Bowel Syndrome (IBS)

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

16: Gastroesophageal Reflux Disease (GERD) references
7: Irritable Bowel Syndrome (IBS) references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Nickel

Only in Gastroesophageal Reflux Disease (GERD)

Nickel DietaryPM2.5 Metals

Only in Irritable Bowel Syndrome (IBS)

None indexed

Metals depleted or redistributed

1 shared

Shared

Zinc

Only in Gastroesophageal Reflux Disease (GERD)

Glutathione (GSH)Iron Magnesium Calcium

Only in Irritable Bowel Syndrome (IBS)

None indexed

Taxa enriched

1 shared

Taxa depleted

2 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii

Only in Gastroesophageal Reflux Disease (GERD)

Streptococcus Blautia Lachnospiraceae Akkermansia muciniphila Actinobacteria (Actinomycetota)Methanobrevibacter Christensenellaceae

Only in Irritable Bowel Syndrome (IBS)

Lactobacillus

Host response elevated

2 shared

Shared

HistamineMast Cell Mediators

Only in Gastroesophageal Reflux Disease (GERD)

IL 6IL-8 (Interleukin-8 / CXCL8)NF KappaBTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)TLR2MMP 3MMP 9COX-2 (Cyclooxygenase-2)INOSProstaglandinsMast CellsCD8 T Cells

Only in Irritable Bowel Syndrome (IBS)

TryptaseSerotonin

Host response depleted

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Claudin 1OccludinDendritic CellsGlutathione (GSH)

Only in Irritable Bowel Syndrome (IBS)

Zinc Dependent Defensins

Ecological state

1 shared

Shared

SIBO

Only in Gastroesophageal Reflux Disease (GERD)

Type I To Type II Esophageal ShiftLPS TLR2 IL6 Claudin1 DIS PathwayStreptococcus Prevotella Co ExclusionSIBO GERD OverlapBile Acid Mucosal DamagePPI Induced Secondary DysbiosisArachidonic Acid Pathway DisruptionBidirectional Gut Brain AxisGram Negative Anaerobe DominanceType I To Type II Microbiome ShiftPPI Driven PH ElevationOral Esophageal TranslocationTLR2 TLR4 ActivationBidirectional Dysbiosis CycleFungal DysbiosisNickel Allergic Mucosal Inflammation

Only in Irritable Bowel Syndrome (IBS)

Nickel Allergic Contact MucositisMast Cell Nerve AxisVisceral HypersensitivityFermentative DysbiosisBarrier Dysfunction

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Gastroesophageal Reflux Disease (GERD)

Nickel-Urease NiFe-HydrogenaseLPS BiosynthesisArachidonic Acid EnzymesTrypsin Like PAR2 ActivatorsABC TransportersTonB Iron TransportBacterial ProteasesFungal LipasesBeta-Glucuronidase

Only in Irritable Bowel Syndrome (IBS)

TLR4 Nickel ActivationMast Cell Degranulation Mediators