Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

19%: weighted overlap
19: shared signals

First condition

Second condition

Comparison

Crohn's DiseaseandLong COVID

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

25: Crohn's Disease references
18: Long COVID references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Arsenic

Only in Crohn's Disease

Iron TissueCobalt MucosalLead Cadmium MercuryIron MucosalCopper Nickel

Only in Long COVID

Zinc Thallium

Metals depleted or redistributed

2 shared

Shared

Glutathione (GSH)Selenium

Only in Crohn's Disease

Zinc LuminalIron LuminalManganese LuminalCopper LuminalZinc Manganese

Only in Long COVID

Iron Copper Nickel

Taxa enriched

5 shared

Taxa depleted

5 shared

Shared

Faecalibacterium prausnitzii Roseburia Lachnospiraceae Akkermansia muciniphila Lactobacillus

Only in Crohn's Disease

Eubacterium Lachnospiraceae (Family)

Only in Long COVID

Bifidobacterium

Host response elevated

2 shared

Shared

Calprotectin (S100A8/A9)Hepcidin

Only in Crohn's Disease

LactoferrinPro Inflammatory CytokinesDUOX2Lipocalin-2 Ceruloplasmin

Only in Long COVID

IL 6TNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)IFN-gamma (Interferon Gamma)LPS In CirculationPD 1 On CD8TIM 3 On CD8AutoantibodiesZinc In Secretions

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Crohn's Disease

Anti Inflammatory CytokinesAlpha Defensins

Only in Long COVID

Regulatory T CellsNK Cell FunctionMemory B CellsSIgAButyrate SeleniumIron In Tissues

Ecological state

2 shared

Shared

Barrier DysfunctionSCFA Depletion

Only in Crohn's Disease

Leaky GutHypoxia BiofilmBile Acid DysmetabolismTryptophan DepletionFermentative Metabolism FerroptosisButyrate CollapseNOD2 Paneth Cell Defect

Only in Long COVID

Self Perpetuating Dysbiosis LoopAnaerobe To Aerobe ShiftSCFA CollapseBacterial Translocation EndotoxemiaGut Lung Axis DisruptionGut Brain Axis DisruptionTryptophan AhR DysmetabolismVirome Co DysbiosisMulti Kingdom DysbiosisNon Linear Recovery TrajectoryStrain Level Diversity CollapseEstrobolome DysfunctionUremic Metabolite AccumulationHypoxia CellularAerobe BloomBacterial TranslocationMulti Kingdom Co DysbiosisNon Linear Recovery

Virulence and functional enzymes

1 shared

Shared

Siderophores

Only in Crohn's Disease

Zinc-MetalloproteaseIron Dependent HydrogenaseCobalt Dependent EnzymesCopper Resistance DeterminantsMucin Degrading EnzymesSiderophores EnterobactinSiderophores YersiniabactinSiderophores AerobactinZinc Metalloprotease BFTFimH AdhesinOuter Membrane VesiclesNickel-Urease

Only in Long COVID

LPS Synthesis TransportAdhesion Invasion FactorsBile Salt Hydrolase (BSH)Beta-GlucuronidasePolysaccharide DegradationLPS Biosynthesis EnzymesBeta Lactamases