Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

18%: weighted overlap
16: shared signals

First condition

Second condition

Comparison

Cerebral PalsyandNecrotizing Enterocolitis

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

9: Cerebral Palsy references
19: Necrotizing Enterocolitis references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Cerebral Palsy

Lead Arsenic Copper

Only in Necrotizing Enterocolitis

Iron

Metals depleted or redistributed

1 shared

Shared

Zinc

Only in Cerebral Palsy

Iron

Only in Necrotizing Enterocolitis

None indexed

Taxa enriched

3 shared

Shared

Enterococcus Klebsiella Klebsiella pneumoniae

Only in Cerebral Palsy

Streptococcus Akkermansia muciniphila Prevotella Veillonella Fusobacterium

Only in Necrotizing Enterocolitis

Escherichia coli Clostridium perfringens StaphylococcusClostridium Perfringens (Toxigenic)Sphingomonas Spp.Clostridium Spp. (Obligate Anaerobe Cluster)Bacteroides/Prevotella (Obligate Anaerobe Cluster)Staphylococcus epidermidis

Taxa depleted

2 shared

Shared

Bacteroides Lactobacillus

Only in Cerebral Palsy

Faecalibacterium prausnitzii Blautia Ruminococcus Roseburia Bacteroides fragilis

Only in Necrotizing Enterocolitis

BifidobacteriumBacteroidetes (Phylum)

Host response elevated

5 shared

Shared

Pro Inflammatory CytokinesTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)Calprotectin (S100A8/A9)IL 6

Only in Cerebral Palsy

IL-8 (Interleukin-8 / CXCL8)IL-10 (Interleukin-10)Hepcidin

Only in Necrotizing Enterocolitis

Lactoferrin EndogenousTLR4 ExpressionLPS

Host response depleted

1 shared

Shared

Zinc

Only in Cerebral Palsy

Iron Butyrate Vitamin D

Only in Necrotizing Enterocolitis

Defensins AcetateLactateSecretory IgA

Ecological state

2 shared

Shared

Proteobacteria BloomBiofilm

Only in Cerebral Palsy

NEC To CP PathwayTLR4 LPS Microglial ActivationOral Gut Inflammatory AxisWhite Matter InjurySCFA DepletionKynurenine Pathway DysregulationOral Gut TranslocationMucin DegradationConstipation Driven Oxygen Shift

Only in Necrotizing Enterocolitis

Proteobacteria Bloom 2 Weeks Pre DiagnosisVirome Convergence 10 Days Pre OnsetTLR4 Upregulation In Premature EpitheliumBifidobacterium Absence As PreconditionHMO Mediated Colonization ResistanceFeed Forward Barrier DestructionTLR4 Feed Forward LoopVirome ConvergenceImmature BarrierParenteral Iron OverloadBile Acid Accumulation ASBT UpregulationMuc2 Depletion Mucosal Barrier FailureObligate Anaerobe Mucosal InvasionGut Brain Axis NDI RiskAntibiotic Driven Richness Nadir Week4

Virulence and functional enzymes

2 shared

Shared

LPS BiosynthesisSiderophores

Only in Cerebral Palsy

TryptophanaseTLR4 LPS SignalingBeta Glucosidase

Only in Necrotizing Enterocolitis

Alpha ToxinPerfringolysin OBiofilm Formation Enzymes