Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

11%: weighted overlap
10: shared signals

First condition

Second condition

Comparison

Breast CancerandAutism Spectrum Disorder

1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

21: Breast Cancer references
32: Autism Spectrum Disorder references
1: shared references

Metals elevated or accumulated

3 shared

Shared

Copper Cadmium Lead

Only in Breast Cancer

None indexed

Only in Autism Spectrum Disorder

Mercury Nickel Arsenic

Metals depleted or redistributed

2 shared

Taxa enriched

0 shared

Shared

None indexed

Only in Breast Cancer

Fusobacterium nucleatum Bacteroides fragilis Acidaminococcus Hungatella Tyzzerella Klebsiella pneumoniae

Only in Autism Spectrum Disorder

Bacteroides Parabacteroides ClostridiumEubacterium CoprostanoligenesDesulfovibrio

Taxa depleted

1 shared

Shared

Bifidobacterium

Only in Breast Cancer

Christensenellaceae Oscillospirales Dialister Akkermansia muciniphila

Only in Autism Spectrum Disorder

Coprococcus Lactobacillus Faecalibacterium prausnitzii Lachnospiraceae

Host response elevated

1 shared

Shared

Hepcidin

Only in Breast Cancer

Metallothionein Ceruloplasmin

Only in Autism Spectrum Disorder

Calprotectin (S100A8/A9)Lactoferrin Transferrin Lipocalin-2 TNF-alpha (Tumor Necrosis Factor Alpha)IL 1IL 6IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Host response depleted

2 shared

Shared

Cu Zn SODGlutathione (GSH)

Only in Breast Cancer

Glutathione PeroxidaseMnSOD

Only in Autism Spectrum Disorder

SulfateZinc IL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx Activity

Ecological state

0 shared

Shared

None indexed

Only in Breast Cancer

Estrogen RecirculationBeta Glucuronidase ActivitySCFA DepletionMetalloestrogen BurdenAlpha Diversity ReductionCross Kingdom Dysbiosis

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Breast Cancer

BFT Zinc MetalloproteaseFadA AdhesinFap2 LectinMMP 9

Only in Autism Spectrum Disorder

ALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production