Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

13%: weighted overlap
11: shared signals

First condition

Second condition

Comparison

Autism Spectrum DisorderandHypertension

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

32: Autism Spectrum Disorder references
14: Hypertension references
0: shared references

Metals elevated or accumulated

3 shared

Shared

Lead Cadmium Nickel

Only in Autism Spectrum Disorder

Mercury Copper Arsenic

Only in Hypertension

None indexed

Metals depleted or redistributed

1 shared

Taxa enriched

0 shared

Shared

None indexed

Only in Autism Spectrum Disorder

Bacteroides Parabacteroides ClostridiumEubacterium CoprostanoligenesDesulfovibrio

Only in Hypertension

Enterobacteriaceae Streptococcus Prevotella Klebsiella pneumoniae Eggerthella Malassezia

Taxa depleted

3 shared

Shared

Bifidobacterium Faecalibacterium prausnitzii Lachnospiraceae

Only in Autism Spectrum Disorder

Coprococcus Lactobacillus

Only in Hypertension

Roseburia Mortierella

Host response elevated

3 shared

Shared

Hepcidin TNF-alpha (Tumor Necrosis Factor Alpha)IL 6

Only in Autism Spectrum Disorder

Calprotectin (S100A8/A9)Lactoferrin Transferrin Lipocalin-2IL 1IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Only in Hypertension

CrpIl 2r AlphaIl 18

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Autism Spectrum Disorder

SulfateZinc IL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Only in Hypertension

Sod

Ecological state

0 shared

Shared

None indexed

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Only in Hypertension

SCFA DepletionElevated Firmicutes Bacteroidetes RatioTMAO ElevationFungal DysbiosisLPS Driven EndotoxemiaBile Acid Disruption

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Autism Spectrum Disorder

Beta-GlucuronidaseALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production

Only in Hypertension

TMA Lyases CutC CutDSiderophoresLPS Biosynthesis EnzymesFungal Lipases