Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

21%: weighted overlap
13: shared signals

First condition

Second condition

Comparison

Anxiety DisordersandDepression

3 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

12: Anxiety Disorders references
38: Depression references
3: shared references

Metals elevated or accumulated

1 shared

Shared

Copper

Only in Anxiety Disorders

None indexed

Only in Depression

Cadmium Lead Mercury

Metals depleted or redistributed

3 shared

Shared

Magnesium Zinc Iron

Only in Anxiety Disorders

None indexed

Only in Depression

Selenium

Taxa enriched

1 shared

Taxa depleted

4 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Lactobacillus Lachnospiraceae

Only in Anxiety Disorders

Roseburia Blautia

Only in Depression

Prevotella Coprococcus Dialister

Host response elevated

0 shared

Shared

None indexed

Only in Anxiety Disorders

Cortisol TNF-alpha (Tumor Necrosis Factor Alpha)IL 6IL-1beta (Interleukin-1 Beta)CRP

Only in Depression

Hepcidin Calprotectin (S100A8/A9)Pro Inflammatory CytokinesCeruloplasmin Ferritin

Host response depleted

0 shared

Shared

None indexed

Only in Anxiety Disorders

Butyrate Serotonin GABA (Gamma-Aminobutyric Acid)BDNF (Brain-Derived Neurotrophic Factor)

Only in Depression

Zinc Magnesium Iron Selenium Glutathione (GSH)Glutathione Peroxidase

Ecological state

2 shared

Shared

SCFA DepletionHPA Axis Dysregulation

Only in Anxiety Disorders

Tryptophan Kynurenine ShuntingVagal Signaling DisruptionGut Barrier Dysfunction

Only in Depression

DysbiosisLeaky GutIntestinal Permeability EndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation

Virulence and functional enzymes

2 shared

Shared

TryptophanaseLPS Biosynthesis Enzymes

Only in Anxiety Disorders

Indoleamine 2 3 Dioxygenase

Only in Depression

Beta-GlucuronidaseLPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseBacterial Amyloids Curli