Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

13%: weighted overlap
9: shared signals

First condition

Second condition

Comparison

Type 1 DiabetesandEpilepsy

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

20: Type 1 Diabetes references
9: Epilepsy references
0: shared references

Metals elevated or accumulated

2 shared

Shared

Arsenic Copper

Only in Type 1 Diabetes

Cadmium Lead Iron

Only in Epilepsy

None indexed

Metals depleted or redistributed

1 shared

Taxa enriched

3 shared

Shared

Streptococcus Veillonella Akkermansia muciniphila

Only in Type 1 Diabetes

Bacteroides Ruminococcus gnavus Escherichia coli Enterobacteriaceae Sutterella Prevotellaceae

Only in Epilepsy

Enterococcus Prevotella

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Roseburia Blautia

Only in Type 1 Diabetes

Bifidobacterium Subdoligranulum Eubacterium rectale Prevotella Lactobacillus LachnospiraceaeClostridium Clusters IV/XIVaEubacterium eligens Clostridium

Only in Epilepsy

Bacteroides Bacteroides fragilis

Host response elevated

0 shared

Shared

None indexed

Only in Type 1 Diabetes

ZnT8 AutoantibodiesGADAIA 2AInsulin AutoantibodiesType 1 IFN SignatureTLR4 NF KB ActivationHepcidin FerritinAnti ZnT8 Autoantibodies

Only in Epilepsy

Calprotectin (S100A8/A9)IL-1beta (Interleukin-1 Beta)IL 6TNF-alpha (Tumor Necrosis Factor Alpha)

Host response depleted

0 shared

Shared

None indexed

Only in Type 1 Diabetes

Glutathione (GSH)Treg FunctionGPR43 SCFA SignalingZinc BioavailabilityZinc Metallothionein

Only in Epilepsy

Butyrate GABA (Gamma-Aminobutyric Acid)

Ecological state

0 shared

Shared

None indexed

Only in Type 1 Diabetes

Butyrate SCFA Ratio ShiftLeaky Gut Precedes OnsetBacterial Translocation To PLNMucin Layer ThinningImmunoinhibitory LPSCVB4 Microbiome SynergyTwo Step Temporal ModelMicrobiome Changes Precede AutoantibodiesBacteroidetes Firmicutes Ratio InversionGut Barrier CompromiseLPS Translocation To PLNSCFA GPR43 Axis DisruptionTreg DepletionViral Dysbiosis TriggerDevelopmental Vulnerability Window

Only in Epilepsy

SCFA DepletionOral Gut TranslocationMucin DegradationKynurenine Pathway ShuntingNeuroinflammation

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Type 1 Diabetes

LPS Biosynthesis GenesIron Acquisition FecB IsdDEFType VI Secretion SystemsDNA Adenine MethyltransferasesLPS BiosynthesisBeta-Glucuronidase

Only in Epilepsy

Beta GlucosidaseTryptophanaseIndoleamine 2 3 Dioxygenase Upregulation