Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

16%: weighted overlap
10: shared signals

First condition

Second condition

Comparison

Type 1 DiabetesandAnxiety Disorders

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

20: Type 1 Diabetes references
12: Anxiety Disorders references
0: shared references

Metals elevated or accumulated

1 shared

Shared

Copper

Only in Type 1 Diabetes

Cadmium Lead Arsenic Iron

Only in Anxiety Disorders

None indexed

Metals depleted or redistributed

1 shared

Taxa enriched

2 shared

Shared

Escherichia coli Prevotellaceae

Only in Type 1 Diabetes

Bacteroides Ruminococcus gnavus Streptococcus Veillonella Enterobacteriaceae Sutterella Akkermansia muciniphila

Only in Anxiety Disorders

Collinsella

Taxa depleted

6 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium Roseburia Lactobacillus Lachnospiraceae Blautia

Only in Type 1 Diabetes

Subdoligranulum Eubacterium rectale PrevotellaClostridium Clusters IV/XIVaEubacterium eligens Clostridium

Only in Anxiety Disorders

None indexed

Host response elevated

0 shared

Shared

None indexed

Only in Type 1 Diabetes

ZnT8 AutoantibodiesGADAIA 2AInsulin AutoantibodiesType 1 IFN SignatureTLR4 NF KB ActivationHepcidin FerritinAnti ZnT8 Autoantibodies

Only in Anxiety Disorders

Cortisol TNF-alpha (Tumor Necrosis Factor Alpha)IL 6IL-1beta (Interleukin-1 Beta)CRP

Host response depleted

0 shared

Shared

None indexed

Only in Type 1 Diabetes

Glutathione (GSH)Treg FunctionGPR43 SCFA SignalingZinc BioavailabilityZinc Metallothionein

Only in Anxiety Disorders

Butyrate Serotonin GABA (Gamma-Aminobutyric Acid)BDNF (Brain-Derived Neurotrophic Factor)

Ecological state

0 shared

Shared

None indexed

Only in Type 1 Diabetes

Butyrate SCFA Ratio ShiftLeaky Gut Precedes OnsetBacterial Translocation To PLNMucin Layer ThinningImmunoinhibitory LPSCVB4 Microbiome SynergyTwo Step Temporal ModelMicrobiome Changes Precede AutoantibodiesBacteroidetes Firmicutes Ratio InversionGut Barrier CompromiseLPS Translocation To PLNSCFA GPR43 Axis DisruptionTreg DepletionViral Dysbiosis TriggerDevelopmental Vulnerability Window

Only in Anxiety Disorders

SCFA DepletionTryptophan Kynurenine ShuntingHPA Axis DysregulationVagal Signaling DisruptionGut Barrier Dysfunction

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Type 1 Diabetes

LPS Biosynthesis GenesIron Acquisition FecB IsdDEFType VI Secretion SystemsDNA Adenine MethyltransferasesLPS BiosynthesisBeta-Glucuronidase

Only in Anxiety Disorders

Indoleamine 2 3 DioxygenaseTryptophanaseLPS Biosynthesis Enzymes