Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

8%: weighted overlap
4: shared signals

First condition

Second condition

Comparison

ObesityandIrritable Bowel Syndrome (IBS)

2 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

31: Obesity references
7: Irritable Bowel Syndrome (IBS) references
2: shared references

Metals elevated or accumulated

1 shared

Shared

Nickel

Only in Obesity

Cadmium Lead Manganese Zinc Iron

Only in Irritable Bowel Syndrome (IBS)

None indexed

Metals depleted or redistributed

0 shared

Shared

None indexed

Only in Obesity

Glutathione (GSH)Magnesium Barium Vanadium Titanium

Only in Irritable Bowel Syndrome (IBS)

Zinc

Taxa enriched

1 shared

Taxa depleted

2 shared

Shared

Faecalibacterium prausnitzii Bifidobacterium

Only in Obesity

Roseburia Lachnospiraceae Akkermansia muciniphila Oscillospiraceae

Only in Irritable Bowel Syndrome (IBS)

Lactobacillus

Host response elevated

0 shared

Shared

None indexed

Only in Obesity

Hepcidin Calprotectin (S100A8/A9)Transferrin Lipocalin-2 Lactoferrin Ferritin

Only in Irritable Bowel Syndrome (IBS)

Mast Cell MediatorsHistamineTryptaseSerotonin

Host response depleted

0 shared

Shared

None indexed

Only in Obesity

Glutathione (GSH)Butyrate Short-Chain Fatty Acids (SCFAs)

Only in Irritable Bowel Syndrome (IBS)

Zinc Dependent Defensins

Ecological state

0 shared

Shared

None indexed

Only in Obesity

HypoxiaMetal Driven DysbiosisReduced SCFA ProductionIncreased LPSEndotoxemiaIntestinal Permeability IncreaseFermentative Metabolism Acidic MicroenvironmentMetabolic EndotoxemiaReduced Microbial DiversityIncreased Energy HarvestBile Acid DysregulationVirome Depletion

Only in Irritable Bowel Syndrome (IBS)

Nickel Allergic Contact MucositisMast Cell Nerve AxisSIBOVisceral HypersensitivityFermentative DysbiosisBarrier Dysfunction

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Obesity

TMA LyaseSiderophores Nickel-UreaseNickel HydrogenaseZinc MetalloproteasesLPS BiosynthesisBeta-Glucuronidase

Only in Irritable Bowel Syndrome (IBS)

TLR4 Nickel ActivationMast Cell Degranulation Mediators