Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 23%
- weighted overlap
- 18
- shared signals
Comparison
FibromyalgiaandDepression
0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 9
- Fibromyalgia references
- 38
- Depression references
- 0
- shared references
Metals depleted or redistributed
3 sharedTaxa enriched
2 sharedShared
Only in Fibromyalgia
Only in Depression
Taxa depleted
3 sharedShared
Only in Fibromyalgia
Only in Depression
Host response elevated
2 sharedHost response depleted
3 sharedEcological state
1 sharedShared
SCFA Depletion
Only in Fibromyalgia
Butyrate ParadoxBarrier DysfunctionTryptophan Kynurenine ShuntingCopper Iron Axis ImbalanceCentral SensitizationGut Barrier Dysfunction
Only in Depression
DysbiosisLeaky GutIntestinal PermeabilityEndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation
Virulence and functional enzymes
3 sharedShared
TryptophanasePro Inflammatory Metabolite SynthesisLPS Biosynthesis
Only in Fibromyalgia
Copper Dependent OxidasesIndoleamine 2 3 DioxygenaseNeurotoxic Metabolite Production
Only in Depression
Beta-GlucuronidaseBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli