Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

13%: weighted overlap
9: shared signals

First condition

Second condition

Comparison

EpilepsyandType 1 Diabetes

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

9: Epilepsy references
20: Type 1 Diabetes references
0: shared references

Metals elevated or accumulated

2 shared

Shared

Copper Arsenic

Only in Epilepsy

None indexed

Only in Type 1 Diabetes

Cadmium Lead Iron

Metals depleted or redistributed

1 shared

Taxa enriched

3 shared

Shared

Akkermansia muciniphila Streptococcus Veillonella

Only in Epilepsy

Enterococcus Prevotella

Only in Type 1 Diabetes

Bacteroides Ruminococcus gnavus Escherichia coli Enterobacteriaceae Sutterella Prevotellaceae

Taxa depleted

3 shared

Shared

Faecalibacterium prausnitzii Blautia Roseburia

Only in Epilepsy

Bacteroides Bacteroides fragilis

Only in Type 1 Diabetes

Bifidobacterium Subdoligranulum Eubacterium rectale Prevotella Lactobacillus LachnospiraceaeClostridium Clusters IV/XIVaEubacterium eligens Clostridium

Host response elevated

0 shared

Shared

None indexed

Only in Epilepsy

Calprotectin (S100A8/A9)IL-1beta (Interleukin-1 Beta)IL 6TNF-alpha (Tumor Necrosis Factor Alpha)

Only in Type 1 Diabetes

ZnT8 AutoantibodiesGADAIA 2AInsulin AutoantibodiesType 1 IFN SignatureTLR4 NF KB ActivationHepcidin FerritinAnti ZnT8 Autoantibodies

Host response depleted

0 shared

Shared

None indexed

Only in Epilepsy

Butyrate GABA (Gamma-Aminobutyric Acid)

Only in Type 1 Diabetes

Glutathione (GSH)Treg FunctionGPR43 SCFA SignalingZinc BioavailabilityZinc Metallothionein

Ecological state

0 shared

Shared

None indexed

Only in Epilepsy

SCFA DepletionOral Gut TranslocationMucin DegradationKynurenine Pathway ShuntingNeuroinflammation

Only in Type 1 Diabetes

Butyrate SCFA Ratio ShiftLeaky Gut Precedes OnsetBacterial Translocation To PLNMucin Layer ThinningImmunoinhibitory LPSCVB4 Microbiome SynergyTwo Step Temporal ModelMicrobiome Changes Precede AutoantibodiesBacteroidetes Firmicutes Ratio InversionGut Barrier CompromiseLPS Translocation To PLNSCFA GPR43 Axis DisruptionTreg DepletionViral Dysbiosis TriggerDevelopmental Vulnerability Window

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Epilepsy

Beta GlucosidaseTryptophanaseIndoleamine 2 3 Dioxygenase Upregulation

Only in Type 1 Diabetes

LPS Biosynthesis GenesIron Acquisition FecB IsdDEFType VI Secretion SystemsDNA Adenine MethyltransferasesLPS BiosynthesisBeta-Glucuronidase