Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

22%: weighted overlap
18: shared signals

First condition

Second condition

Comparison

DepressionandHashimoto's Thyroiditis

1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

38: Depression references
17: Hashimoto's Thyroiditis references
1: shared references

Metals elevated or accumulated

4 shared

Shared

Cadmium Lead Mercury Copper

Only in Depression

None indexed

Only in Hashimoto's Thyroiditis

Iodine ExcessNickel

Metals depleted or redistributed

3 shared

Shared

Zinc Iron Selenium

Only in Depression

Magnesium

Only in Hashimoto's Thyroiditis

None indexed

Taxa enriched

0 shared

Shared

None indexed

Only in Depression

Candida albicans Clostridium Bacteroides fragilis Escherichia coli Eggerthella Enterobacteriaceae Flavonifractor

Only in Hashimoto's Thyroiditis

Proteobacteria (Pseudomonadota)Actinobacteria (Actinomycetota)Blautia Dorea Prevotella Akkermansia muciniphila Bifidobacterium Intestinimonas Turicibacter Klebsiella pneumoniae

Taxa depleted

5 shared

Host response elevated

3 shared

Shared

Hepcidin Calprotectin (S100A8/A9)Ceruloplasmin

Only in Depression

Pro Inflammatory CytokinesFerritin

Only in Hashimoto's Thyroiditis

Advanced Glycation End Products

Host response depleted

1 shared

Shared

Glutathione Peroxidase

Only in Depression

Zinc Magnesium Iron Selenium Glutathione (GSH)

Only in Hashimoto's Thyroiditis

Selenium Dependent GPxSelenium Dependent TrxRButyrateValeric AcidThioredoxin ReductaseSelenium Dependent Selenoproteins

Ecological state

1 shared

Shared

SCFA Depletion

Only in Depression

DysbiosisLeaky GutIntestinal Permeability EndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation

Only in Hashimoto's Thyroiditis

Molecular MimicryIodine Driven DysbiosisTh17 Treg ImbalanceTryptophan Metabolism DisruptionBile Acid DysmetabolismButyrate DepletionOxidative Stress

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Depression

TryptophanaseLPS BiosynthesisPro Inflammatory Metabolite SynthesisBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli

Only in Hashimoto's Thyroiditis

Bacterial DeiodinasesLPS EndotoxinIDO1 Kynurenine AhR PathwayThyroid Peroxidase Mimics