Comparative evidence
Compare conditions
Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.
- 23%
- weighted overlap
- 18
- shared signals
Comparison
DepressionandFibromyalgia
0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.
- 38
- Depression references
- 9
- Fibromyalgia references
- 0
- shared references
Metals depleted or redistributed
3 sharedTaxa enriched
2 sharedShared
Only in Depression
Only in Fibromyalgia
Taxa depleted
3 sharedShared
Only in Depression
Only in Fibromyalgia
Host response elevated
2 sharedHost response depleted
3 sharedEcological state
1 sharedShared
SCFA Depletion
Only in Depression
DysbiosisLeaky GutIntestinal PermeabilityEndotoxemiaLow SCFA ProductionImpaired Tryptophan MetabolismReduced Indole ProductionHPA Axis DysregulationTryptophan Shunting IDOHPA Axis HyperactivationBlood Brain Barrier DisruptionNeuroinflammation
Only in Fibromyalgia
Butyrate ParadoxBarrier DysfunctionTryptophan Kynurenine ShuntingCopper Iron Axis ImbalanceCentral SensitizationGut Barrier Dysfunction
Virulence and functional enzymes
3 sharedShared
TryptophanaseLPS BiosynthesisPro Inflammatory Metabolite Synthesis
Only in Depression
Beta-GlucuronidaseBiofilm Formation EnzymesIndoleamine 2 3 Dioxygenase IDOBacterial TryptophanaseLPS Biosynthesis EnzymesBacterial Amyloids Curli
Only in Fibromyalgia
Copper Dependent OxidasesIndoleamine 2 3 DioxygenaseNeurotoxic Metabolite Production