Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

18%: weighted overlap
17: shared signals

First condition

Second condition

Comparison

Crohn's DiseaseandHashimoto's Thyroiditis

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

25: Crohn's Disease references
17: Hashimoto's Thyroiditis references
0: shared references

Metals elevated or accumulated

5 shared

Shared

Lead Cadmium Mercury Copper Nickel

Only in Crohn's Disease

Iron TissueCobalt MucosalArsenicIron Mucosal

Only in Hashimoto's Thyroiditis

Iodine Excess

Metals depleted or redistributed

2 shared

Shared

Zinc Selenium

Only in Crohn's Disease

Zinc LuminalIron LuminalManganese LuminalCopper LuminalGlutathione (GSH)Manganese

Only in Hashimoto's Thyroiditis

Iron

Taxa enriched

0 shared

Shared

None indexed

Only in Crohn's Disease

Escherichia coli Fusobacterium nucleatum Enterococcus Ruminococcus gnavus Bacteroides fragilis Candida albicans Collinsella Debaryomyces Enterobacteriaceae

Only in Hashimoto's Thyroiditis

Proteobacteria (Pseudomonadota)Actinobacteria (Actinomycetota)Blautia Dorea Prevotella Akkermansia muciniphila Bifidobacterium Intestinimonas Turicibacter Klebsiella pneumoniae

Taxa depleted

5 shared

Host response elevated

3 shared

Shared

Calprotectin (S100A8/A9)Hepcidin Ceruloplasmin

Only in Crohn's Disease

LactoferrinPro Inflammatory CytokinesDUOX2Lipocalin-2

Only in Hashimoto's Thyroiditis

Advanced Glycation End Products

Host response depleted

0 shared

Shared

None indexed

Only in Crohn's Disease

Glutathione (GSH)Anti Inflammatory CytokinesAlpha Defensins

Only in Hashimoto's Thyroiditis

Selenium Dependent GPxSelenium Dependent TrxRButyrateValeric AcidGlutathione PeroxidaseThioredoxin ReductaseSelenium Dependent Selenoproteins

Ecological state

2 shared

Shared

SCFA DepletionBile Acid Dysmetabolism

Only in Crohn's Disease

Barrier DysfunctionLeaky GutHypoxia BiofilmTryptophan DepletionFermentative Metabolism FerroptosisButyrate CollapseNOD2 Paneth Cell Defect

Only in Hashimoto's Thyroiditis

Molecular MimicryIodine Driven DysbiosisTh17 Treg ImbalanceTryptophan Metabolism DisruptionButyrate DepletionOxidative Stress

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Crohn's Disease

Siderophores Zinc-MetalloproteaseIron Dependent HydrogenaseCobalt Dependent EnzymesCopper Resistance DeterminantsMucin Degrading EnzymesSiderophores EnterobactinSiderophores YersiniabactinSiderophores AerobactinZinc Metalloprotease BFTFimH AdhesinOuter Membrane VesiclesNickel-Urease

Only in Hashimoto's Thyroiditis

Bacterial DeiodinasesBeta-GlucuronidaseLPS EndotoxinIDO1 Kynurenine AhR PathwayThyroid Peroxidase Mimics