Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

15%: weighted overlap
10: shared signals

First condition

Second condition

Comparison

Celiac DiseaseandType 1 Diabetes

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

8: Celiac Disease references
20: Type 1 Diabetes references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Celiac Disease

Nickel

Only in Type 1 Diabetes

Cadmium Lead Arsenic Iron Copper

Metals depleted or redistributed

2 shared

Taxa enriched

1 shared

Shared

Escherichia coli

Only in Celiac Disease

Bacteroides fragilis Proteobacteria (Pseudomonadota)Staphylococcus aureus

Only in Type 1 Diabetes

Bacteroides Ruminococcus gnavus Streptococcus Veillonella Enterobacteriaceae Sutterella Akkermansia muciniphila Prevotellaceae

Taxa depleted

5 shared

Shared

Bifidobacterium Lactobacillus Faecalibacterium prausnitzii Lachnospiraceae Prevotella

Only in Celiac Disease

None indexed

Only in Type 1 Diabetes

Roseburia Subdoligranulum Eubacterium rectaleClostridium Clusters IV/XIVaBlautia Eubacterium eligens Clostridium

Host response elevated

0 shared

Shared

None indexed

Only in Celiac Disease

Zonulin

Only in Type 1 Diabetes

ZnT8 AutoantibodiesGADAIA 2AInsulin AutoantibodiesType 1 IFN SignatureTLR4 NF KB ActivationHepcidin FerritinAnti ZnT8 Autoantibodies

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Celiac Disease

None indexed

Only in Type 1 Diabetes

Treg FunctionGPR43 SCFA SignalingZinc BioavailabilityZinc Metallothionein

Ecological state

0 shared

Shared

None indexed

Only in Celiac Disease

Villous AtrophyIncreased Intestinal PermeabilityGluten Mediated Tight Junction DisassemblyNickel Allergic Contact Mucositis

Only in Type 1 Diabetes

Butyrate SCFA Ratio ShiftLeaky Gut Precedes OnsetBacterial Translocation To PLNMucin Layer ThinningImmunoinhibitory LPSCVB4 Microbiome SynergyTwo Step Temporal ModelMicrobiome Changes Precede AutoantibodiesBacteroidetes Firmicutes Ratio InversionGut Barrier CompromiseLPS Translocation To PLNSCFA GPR43 Axis DisruptionTreg DepletionViral Dysbiosis TriggerDevelopmental Vulnerability Window

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Celiac Disease

Bacterial ProteasesTissue Transglutaminase 2 Mimicry

Only in Type 1 Diabetes

LPS Biosynthesis GenesIron Acquisition FecB IsdDEFType VI Secretion SystemsDNA Adenine MethyltransferasesLPS Biosynthesis