Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

19%: weighted overlap
17: shared signals

First condition

Second condition

Comparison

Autism Spectrum DisorderandHashimoto's Thyroiditis

1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

32: Autism Spectrum Disorder references
17: Hashimoto's Thyroiditis references
1: shared references

Metals elevated or accumulated

5 shared

Shared

Lead Mercury Cadmium Copper Nickel

Only in Autism Spectrum Disorder

Arsenic

Only in Hashimoto's Thyroiditis

Iodine Excess

Metals depleted or redistributed

3 shared

Shared

Zinc Iron Selenium

Only in Autism Spectrum Disorder

Glutathione (GSH)

Only in Hashimoto's Thyroiditis

None indexed

Taxa enriched

0 shared

Shared

None indexed

Only in Autism Spectrum Disorder

Bacteroides Parabacteroides ClostridiumEubacterium CoprostanoligenesDesulfovibrio

Only in Hashimoto's Thyroiditis

Proteobacteria (Pseudomonadota)Actinobacteria (Actinomycetota)Blautia Dorea Prevotella Akkermansia muciniphila Bifidobacterium Intestinimonas Turicibacter Klebsiella pneumoniae

Taxa depleted

5 shared

Shared

Coprococcus Bifidobacterium Lactobacillus Faecalibacterium prausnitzii Lachnospiraceae

Only in Autism Spectrum Disorder

None indexed

Only in Hashimoto's Thyroiditis

Akkermansia muciniphila Roseburia

Host response elevated

2 shared

Shared

Calprotectin (S100A8/A9)Hepcidin

Only in Autism Spectrum Disorder

Lactoferrin Transferrin Lipocalin-2 TNF-alpha (Tumor Necrosis Factor Alpha)IL 1IL 6IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Only in Hashimoto's Thyroiditis

CeruloplasminAdvanced Glycation End Products

Host response depleted

0 shared

Shared

None indexed

Only in Autism Spectrum Disorder

Glutathione (GSH)SulfateZinc IL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Only in Hashimoto's Thyroiditis

Selenium Dependent GPxSelenium Dependent TrxRButyrateValeric AcidGlutathione PeroxidaseThioredoxin ReductaseSelenium Dependent Selenoproteins

Ecological state

1 shared

Shared

Oxidative Stress

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Only in Hashimoto's Thyroiditis

Molecular MimicryIodine Driven DysbiosisTh17 Treg ImbalanceSCFA DepletionTryptophan Metabolism DisruptionBile Acid DysmetabolismButyrate Depletion

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Autism Spectrum Disorder

ALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production

Only in Hashimoto's Thyroiditis

Bacterial DeiodinasesLPS EndotoxinIDO1 Kynurenine AhR PathwayThyroid Peroxidase Mimics