Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

14%: weighted overlap
10: shared signals

First condition

Second condition

Comparison

Autism Spectrum DisorderandCeliac Disease

1 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

32: Autism Spectrum Disorder references
8: Celiac Disease references
1: shared references

Metals elevated or accumulated

1 shared

Shared

Nickel

Only in Autism Spectrum Disorder

Lead Mercury Cadmium Copper Arsenic

Only in Celiac Disease

None indexed

Metals depleted or redistributed

3 shared

Taxa enriched

0 shared

Shared

None indexed

Only in Autism Spectrum Disorder

Bacteroides Parabacteroides ClostridiumEubacterium CoprostanoligenesDesulfovibrio

Only in Celiac Disease

Escherichia coli Bacteroides fragilis Proteobacteria (Pseudomonadota)Staphylococcus aureus

Taxa depleted

4 shared

Shared

Bifidobacterium Lactobacillus Faecalibacterium prausnitzii Lachnospiraceae

Only in Autism Spectrum Disorder

Coprococcus

Only in Celiac Disease

Prevotella

Host response elevated

0 shared

Shared

None indexed

Only in Autism Spectrum Disorder

Calprotectin (S100A8/A9)Lactoferrin Transferrin Hepcidin Lipocalin-2 TNF-alpha (Tumor Necrosis Factor Alpha)IL 1IL 6IL 2IL-17 (Interleukin-17)IFN-gamma (Interferon Gamma)NF KappaBMalondialdehydeFolate Receptor AutoantibodiesPropionic AcidMetallothionein InducedInflammatory Cytokines

Only in Celiac Disease

Zonulin

Host response depleted

1 shared

Shared

Glutathione (GSH)

Only in Autism Spectrum Disorder

SulfateZinc IL-10 (Interleukin-10)TGF-beta (Transforming Growth Factor Beta)NRF2 FunctionZO 1ClaudinsOccludinZinc MetalloenzymesGPx ActivityCu Zn SOD

Only in Celiac Disease

None indexed

Ecological state

0 shared

Shared

None indexed

Only in Autism Spectrum Disorder

Gut Barrier DysfunctionPropionic Acid NeurotoxicityOxidative StressBBB DisruptionDemyelinationExcitatory Inhibitory ImbalanceOne Carbon Metabolism DisruptionSulfate DepletionEarly Antibiotic DisruptionMaternal Microbiome TransmissionMicrobial Zinc CompetitionMetal Profile Not Single MetalGut Barrier DisruptionMis-MetallationPropionic Acid ElevationSCFA ImbalanceNeuroinflammationDevelopmental Vulnerability

Only in Celiac Disease

Villous AtrophyIncreased Intestinal PermeabilityGluten Mediated Tight Junction DisassemblyNickel Allergic Contact Mucositis

Virulence and functional enzymes

1 shared

Shared

Beta-Glucuronidase

Only in Autism Spectrum Disorder

ALA Dehydrase Inhibited By PbCNPase Inhibited By PbHydrogen Sulfide ProductionPropionic Acid Production

Only in Celiac Disease

Bacterial ProteasesTissue Transglutaminase 2 Mimicry