Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

10%: weighted overlap
7: shared signals

First condition

Second condition

Comparison

Necrotizing EnterocolitisandUlcerative Colitis

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

19: Necrotizing Enterocolitis references
6: Ulcerative Colitis references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Necrotizing Enterocolitis

Iron

Only in Ulcerative Colitis

CopperIron LuminalThallium

Metals depleted or redistributed

1 shared

Shared

Zinc

Only in Necrotizing Enterocolitis

None indexed

Only in Ulcerative Colitis

Iron SystemicSelenium Manganese

Taxa enriched

2 shared

Shared

Escherichia coli Enterococcus

Only in Necrotizing Enterocolitis

Klebsiella Clostridium perfringens Staphylococcus Klebsiella pneumoniaeClostridium Perfringens (Toxigenic)Sphingomonas Spp.Clostridium Spp. (Obligate Anaerobe Cluster)Bacteroides/Prevotella (Obligate Anaerobe Cluster)Staphylococcus epidermidis

Only in Ulcerative Colitis

Fusobacterium nucleatum Ruminococcus gnavus

Taxa depleted

1 shared

Host response elevated

1 shared

Shared

Calprotectin (S100A8/A9)

Only in Necrotizing Enterocolitis

Lactoferrin EndogenousPro Inflammatory CytokinesTLR4 ExpressionLPSTNF-alpha (Tumor Necrosis Factor Alpha)IL-1beta (Interleukin-1 Beta)IL 6

Only in Ulcerative Colitis

Lactoferrin Hepcidin Ceruloplasmin Copper

Host response depleted

1 shared

Shared

Zinc

Only in Necrotizing Enterocolitis

Defensins AcetateLactateSecretory IgA

Only in Ulcerative Colitis

SeleniumGlutathione Peroxidase

Ecological state

0 shared

Shared

None indexed

Only in Necrotizing Enterocolitis

Proteobacteria Bloom 2 Weeks Pre DiagnosisVirome Convergence 10 Days Pre OnsetTLR4 Upregulation In Premature EpitheliumBifidobacterium Absence As PreconditionHMO Mediated Colonization ResistanceFeed Forward Barrier DestructionProteobacteria BloomTLR4 Feed Forward LoopVirome ConvergenceImmature BarrierParenteral Iron OverloadBiofilmBile Acid Accumulation ASBT UpregulationMuc2 Depletion Mucosal Barrier FailureObligate Anaerobe Mucosal InvasionGut Brain Axis NDI RiskAntibiotic Driven Richness Nadir Week4

Only in Ulcerative Colitis

Iron Pathobiont Feedback LoopButyrate DepletionMucosal UlcerationBarrier DysfunctionTh17 Treg ImbalanceMucin Degradation

Virulence and functional enzymes

1 shared

Shared

Siderophores

Only in Necrotizing Enterocolitis

LPS BiosynthesisAlpha ToxinPerfringolysin OBiofilm Formation Enzymes

Only in Ulcerative Colitis

Iron Acquisition SystemsAdhesinsMucin Degrading Glycosidases