Comparative evidence

Compare conditions

Put two canonical disease records side by side. The result is a shareable, deterministic comparison of what is shared, what is unique, and how much evidence each record currently carries.

8%: weighted overlap
5: shared signals

First condition

Second condition

Comparison

Irritable Bowel Syndrome (IBS)andType 1 Diabetes

0 references occur in both reconciled evidence sets. Shared signals do not establish shared causes, diagnoses, or treatments.

7: Irritable Bowel Syndrome (IBS) references
20: Type 1 Diabetes references
0: shared references

Metals elevated or accumulated

0 shared

Shared

None indexed

Only in Irritable Bowel Syndrome (IBS)

Nickel

Only in Type 1 Diabetes

Cadmium Lead Arsenic Iron Copper

Metals depleted or redistributed

1 shared

Shared

Zinc

Only in Irritable Bowel Syndrome (IBS)

None indexed

Only in Type 1 Diabetes

Glutathione (GSH)Selenium

Taxa enriched

1 shared

Taxa depleted

3 shared

Shared

Lactobacillus Bifidobacterium Faecalibacterium prausnitzii

Only in Irritable Bowel Syndrome (IBS)

None indexed

Only in Type 1 Diabetes

Roseburia Subdoligranulum Eubacterium rectale Prevotella LachnospiraceaeClostridium Clusters IV/XIVaBlautia Eubacterium eligens Clostridium

Host response elevated

0 shared

Shared

None indexed

Only in Irritable Bowel Syndrome (IBS)

Mast Cell MediatorsHistamineTryptaseSerotonin

Only in Type 1 Diabetes

ZnT8 AutoantibodiesGADAIA 2AInsulin AutoantibodiesType 1 IFN SignatureTLR4 NF KB ActivationHepcidin FerritinAnti ZnT8 Autoantibodies

Host response depleted

0 shared

Shared

None indexed

Only in Irritable Bowel Syndrome (IBS)

Zinc Dependent Defensins

Only in Type 1 Diabetes

Glutathione (GSH)Treg FunctionGPR43 SCFA SignalingZinc BioavailabilityZinc Metallothionein

Ecological state

0 shared

Shared

None indexed

Only in Irritable Bowel Syndrome (IBS)

Nickel Allergic Contact MucositisMast Cell Nerve AxisSIBOVisceral HypersensitivityFermentative DysbiosisBarrier Dysfunction

Only in Type 1 Diabetes

Butyrate SCFA Ratio ShiftLeaky Gut Precedes OnsetBacterial Translocation To PLNMucin Layer ThinningImmunoinhibitory LPSCVB4 Microbiome SynergyTwo Step Temporal ModelMicrobiome Changes Precede AutoantibodiesBacteroidetes Firmicutes Ratio InversionGut Barrier CompromiseLPS Translocation To PLNSCFA GPR43 Axis DisruptionTreg DepletionViral Dysbiosis TriggerDevelopmental Vulnerability Window

Virulence and functional enzymes

0 shared

Shared

None indexed

Only in Irritable Bowel Syndrome (IBS)

TLR4 Nickel ActivationMast Cell Degranulation Mediators

Only in Type 1 Diabetes

LPS Biosynthesis GenesIron Acquisition FecB IsdDEFType VI Secretion SystemsDNA Adenine MethyltransferasesLPS BiosynthesisBeta-Glucuronidase