Host defenses12 sources
Antimicrobial Metals
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Search: “nutritional-immunity”
Ranked matches across titles, topics, categories, and article introductions, filtered to defense.
23 records in this view
A
Host defenses3 sources
Autoimmunity
Autoimmunity occurs when the immune system attacks the body's own tissues. What has emerged over the past two decades is that the gut microbiome is not merely associated with autoimmune disease -- it is a mechanistic driver of immune tolerance breakdown. Metals add a se…
B
Host defenses4 sources
Biofilm
Structured microbial communities encased in a self-produced extracellular polymeric substance (EPS) matrix. Biofilms are the predominant mode of bacterial and fungal growth in chronic infections, device-associated infections, and the gut. From a metallomics perspective,…
C
Host defenses4 sources
Calprotectin (S100A8/A9)
A heterodimer of S100A8 and S100A9 calcium-binding proteins that constitutes approximately 60% of the cytosolic protein content of neutrophils. Calprotectin is a central effector of nutritional immunity, sequestering essential transition metals from invading pathogens a…
D
Host defenses4 sources
Dietary Iron and Gut Ecology
iron occupies a unique position among dietary metals: it is both an essential nutrient and a selective pressure that shapes the gut microbial ecosystem. The form, quantity, and bioavailability of dietary iron determines which microbes thrive and which are competitively …
Host defenses6 sources
Dyshomeostasis
The pathological disruption of normal metal homeostasis — the tightly regulated balance of essential trace elements (iron, zinc, copper, manganese, selenium, cobalt) and the effective exclusion of toxic metals (cadmium, lead, mercury, arsenic). Dyshomeostasis is a conve…
F
Host defenses3 sources
Ferritin
The primary intracellular iron storage protein, capable of sequestering up to 4,500 iron atoms in a single molecule as a mineralized ferric oxyhydroxide core. Ferritin is one of the most elegant solutions evolution has produced for the iron paradox: iron is essential fo…
Host defenses3 sources
Ferroportin
The only known cellular iron exporter in mammals. Encoded by the SLC40A1 gene, ferroportin (FPN) sits on the basolateral membrane of enterocytes, the surface of macrophages, and the membrane of hepatocytes, controlling the flow of iron from these cells into the bloodstr…
H
Host defenses6 sources
Hepcidin
The master regulator of systemic iron homeostasis. Hepcidin is a 25-amino-acid peptide hormone produced primarily by hepatocytes that controls iron absorption, recycling, and distribution by binding to and degrading ferroportin (SLC40A1/FPN) -- the only known cellular i…
I
Host defenses5 sources
IFN-gamma (Interferon Gamma)
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Host defenses6 sources
Innate Immunity
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Host defenses12 sources
Inter-Kingdom Metal Shielding
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
L
Host defenses5 sources
Lactoferrin
An iron-binding glycoprotein of the transferrin family that sequesters iron (and potentially other metals) from pathogens at mucosal surfaces and sites of inflammation. Lactoferrin is a key effector of nutritional immunity, complementing calprotectin's role in metal res…
Host defenses8 sources
Lipocalin-2
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
M
Host defenses3 sources
Metal Homeostasis
The biological processes by which organisms maintain proper intracellular and systemic concentrations of essential metals -- importing what is needed, storing excess safely, and exporting or sequestering surplus. Both host and microbial systems have evolved elaborate me…
Host defenses8 sources
Metal-Dependent Virulence
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Host defenses13 sources
Microbial Metallomics
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
P
Host defenses11 sources
Pathogen Metal Acquisition Systems
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
S
Host defenses5 sources
Siderophore Competition
Small, high-affinity iron-chelating molecules secreted by bacteria and fungi to scavenge ferric iron (Fe3+) from the environment. Siderophore competition is a fundamental ecological force in the gut microbiome: organisms with superior iron acquisition systems gain a dec…
Host defenses14 sources
Siderophores
Siderophores are small, high-affinity iron-chelating molecules secreted by bacteria, fungi, and some plants to scavenge ferric iron (Fe3+) from their environment. In the context of infection, siderophores are the molecular weapons pathogens deploy to break through nutri…
Host defenses7 sources
Siderophores and Metallophores
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Host defenses12 sources
Superoxide Dismutase
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
T
Host defenses8 sources
Transferrin
This knowledge-base record is being expanded from WikiBiome’s evidence graph.