Search: “metal-sequestration”

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Host defenses4 sources

Calprotectin (S100A8/A9)

A heterodimer of S100A8 and S100A9 calcium-binding proteins that constitutes approximately 60% of the cytosolic protein content of neutrophils. Calprotectin is a central effector of nutritional immunity, sequestering essential transition metals from invading pathogens a…

Host defenses11 sources

Nutritional Immunity (Metal Sequestration)

The strategy by which mammalian hosts withhold essential metals from invading pathogens to limit their growth. Well-established for iron and zinc; underexplored but potentially powerful for nickel.