Mechanisms4 sources
BDNF (Brain-Derived Neurotrophic Factor)
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Search: “depression”
Ranked matches across titles, topics, categories, and article introductions, filtered to mechanism.
13 records in this view
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Mechanisms4 sources
Ceruloplasmin
The major copper-carrying protein in human blood, binding approximately 95% of circulating copper. Ceruloplasmin is far more than a passive transport vehicle -- it is a multicopper oxidase with ferroxidase activity, an acute-phase reactant that rises with inflammation, …
Mechanisms3 sources
Comorbidities
The co-occurrence of multiple diseases in the same individual at rates exceeding chance. Comorbidity patterns are a central puzzle in medicine -- why do IBD patients develop CVD? Why does PCOS cluster with T2D? Why do neurodegenerative diseases associate with depression…
Mechanisms4 sources
Copper Dysregulation
Perhaps the most pervasive metallomic finding across human disease: copper is elevated in nearly every pathological condition examined in this wiki -- cancer (pan-cancer), PCOS, cardiovascular disease, depression, schizophrenia, IBD, and rheumatoid arthritis. Simultaneo…
Mechanisms5 sources
Cortisol
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
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Mechanisms8 sources
GABA (Gamma-Aminobutyric Acid)
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Mechanisms16 sources
Gut-Brain Axis
Bidirectional communication between the gut microbiota and the central nervous system, mediated by neural (vagus nerve, enteric nervous system), immune (cytokines, microglia), endocrine (HPA axis), and metabolic (SCFAs, neurotransmitter precursors, tryptophan metabolite…
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Mechanisms4 sources
IL-8 (Interleukin-8 / CXCL8)
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Mechanisms13 sources
Interleukin-6 (IL-6)
Interleukin-6 is a pleiotropic cytokine that sits at the crossroads of innate immunity, adaptive immunity, and metabolism. It is one of the most frequently elevated inflammatory mediators across conditions in this wiki — appearing in disease signatures spanning IBD, aut…
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Mechanisms10 sources
Kynurenine Pathway
The kynurenine pathway (KP) is the dominant route of tryptophan catabolism, accounting for approximately 95% of dietary tryptophan degradation. It produces a cascade of neuroactive, immunomodulatory, and potentially neurotoxic metabolites whose balance determines whethe…
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Mechanisms8 sources
Nickel Neurotoxicity
Chronic nickel exposure can damage the central nervous system, causing behavioral and cognitive deficits through oxidative stress in the hippocampus and disruption of multiple neurotransmitter systems.
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Mechanisms5 sources
Serotonin-Estrogen Axis
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
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Mechanisms9 sources
Tryptophan Metabolism
Tryptophan (Trp) is an essential amino acid metabolized via three competing pathways: the kynurenine pathway, the serotonin pathway, and the microbial indole pathway. The balance among these pathways is profoundly influenced by the gut microbiome, inflammation, and meta…