WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions, filtered to mechanism.
Amyloid-beta (Aβ) is a 36–43 amino acid peptide derived from the proteolytic cleavage of amyloid precursor protein (APP) by beta-secretase (BACE1) and gamma-secretase. Its aggregation from soluble monomers into insoluble fibrillar plaques in the brain is the defining ne…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
A selective semipermeable border formed by brain endothelial cells connected by tight junctions, pericytes, and astrocytic end-feet. The BBB restricts passage of most molecules from blood to brain, protecting the CNS from toxins, pathogens, and inflammatory mediators. M…
Disruption of the normal composition and metabolic function of microbial communities, particularly the gut microbiome. In the metallomics context, dysbiosis is both a consequence of metal toxicity and an amplifier of further disease -- creating vicious cycles where meta…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Gut barrier dysfunction -- colloquially "leaky gut" -- is the pathological increase in intestinal permeability that permits translocation of bacteria, bacterial products (LPS, peptidoglycan), metals, and dietary antigens from the gut lumen into the systemic circulation.…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
The intestinal epithelium is a single-cell-thick barrier separating the lumen -- home to trillions of microbes and ingested metals -- from the systemic circulation. When this barrier fails, the consequences cascade: microbial products translocate, metals gain unrestrict…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Microglia are the resident immune cells of the central nervous system, constituting 5-12% of all brain cells. They function as the brain's surveillance and defense system -- scanning for damage, clearing debris, pruning synapses during development, and mounting inflamma…
Mitochondrial dysfunction refers to the impairment of mitochondrial energy production, redox balance, and signaling functions. Mitochondria are the primary targets of heavy metal toxicity in human cells, and they are also the organelles most dependent on metal cofactors…
Chronic inflammatory activation within the central nervous system, driven by microglia, astrocytes, and infiltrating peripheral immune cells. Neuroinflammation is a convergent pathological mechanism across alzheimers disease, parkinsons disease, multiple sclerosis, and …
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kB) is a family of transcription factors that regulate inflammation, immune responses, cell survival, and proliferation. NF-kB is a convergence point where metal toxicity, pathogen signaling, and chronic…
The outer membrane (OM) is the defining structural feature of Gram-negative bacteria, providing a permeability barrier that profoundly influences metal acquisition, antibiotic resistance, immune activation, and virulence. For the microbiome-metal axis, the outer membran…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.