WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
The most common malignancy of the stomach, accounting for over 95% of gastric cancers. helicobacter pylori infection is the strongest known risk factor, classified as a Group 1 carcinogen by IARC. In the metallomics framework, gastric adenocarcinoma reveals a striking d…
The fifth most common cancer worldwide and third leading cause of cancer death, with over 1 million new cases annually. Gastric cancer stands unique in this wiki as the disease where a single microorganism -- helicobacter pylori -- provides the dominant causal pathway, …
A breach in the gastric mucosal lining extending through the muscularis mucosae, most commonly caused by helicobacter pylori infection or chronic NSAID use. Gastric ulceration represents a critical node in the upper GI disease continuum, linking gerd, chronic gastritis,…
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Alphabetical definitions of specialist terms used throughout this wiki. Where a full concept page exists, the term links to it. --- AhR (aryl hydrocarbon receptor) -- A ligand-activated transcription factor that senses microbial metabolites (especially indoles from tryp…
Haemophilus is a genus of small, Gram-negative, facultatively anaerobic coccobacilli that inhabit the upper respiratory tract, oral cavity, and gastrointestinal tract. The genus name literally means "blood-loving" -- a direct reference to its absolute requirement for he…
A gastric pathogen that is arguably the most nickel-dependent human pathogen known. Two of its key virulence factors — urease and [NiFe] hydrogenase — require nickel, and the bacterium has evolved an elaborate nickel trafficking, storage, and regulation system to suppor…
[NiFe] hydrogenases are the second major nickel-dependent virulence factor class in human pathogens. Less widespread than urease but critical for energy metabolism in gastric, enteric, and intracellular pathogens. The discovery that H. pylori hydrogenase powers CagA tra…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Research summary -- not medical advice. This page synthesizes published research on why a commonly prescribed intervention may be counterproductive in this specific clinical context. Consult a qualified healthcare provider before making any changes to treatment.
A non-essential metal with a dual toxicological profile: inorganic tin (from canned foods) causes primarily gastric irritation at high concentrations, while organotin compounds (tributyltin, trimethyltin) are far more toxic, acting as endocrine disruptors and neurotoxin…