Host defenses12 sources
Antimicrobial Metals
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Search: “metals”
Ranked matches across titles, topics, categories, and article introductions, filtered to defense.
14 records in this view
A
Host defenses3 sources
Autoimmunity
Autoimmunity occurs when the immune system attacks the body's own tissues. What has emerged over the past two decades is that the gut microbiome is not merely associated with autoimmune disease -- it is a mechanistic driver of immune tolerance breakdown. Metals add a se…
B
Host defenses4 sources
Biofilm
Structured microbial communities encased in a self-produced extracellular polymeric substance (EPS) matrix. Biofilms are the predominant mode of bacterial and fungal growth in chronic infections, device-associated infections, and the gut. From a metallomics perspective,…
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Host defenses4 sources
Calprotectin (S100A8/A9)
A heterodimer of S100A8 and S100A9 calcium-binding proteins that constitutes approximately 60% of the cytosolic protein content of neutrophils. Calprotectin is a central effector of nutritional immunity, sequestering essential transition metals from invading pathogens a…
D
Host defenses4 sources
Dietary Iron and Gut Ecology
iron occupies a unique position among dietary metals: it is both an essential nutrient and a selective pressure that shapes the gut microbial ecosystem. The form, quantity, and bioavailability of dietary iron determines which microbes thrive and which are competitively …
Host defenses6 sources
Dyshomeostasis
The pathological disruption of normal metal homeostasis — the tightly regulated balance of essential trace elements (iron, zinc, copper, manganese, selenium, cobalt) and the effective exclusion of toxic metals (cadmium, lead, mercury, arsenic). Dyshomeostasis is a conve…
L
Host defenses5 sources
Lactoferrin
An iron-binding glycoprotein of the transferrin family that sequesters iron (and potentially other metals) from pathogens at mucosal surfaces and sites of inflammation. Lactoferrin is a key effector of nutritional immunity, complementing calprotectin's role in metal res…
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Host defenses3 sources
Metal Homeostasis
The biological processes by which organisms maintain proper intracellular and systemic concentrations of essential metals -- importing what is needed, storing excess safely, and exporting or sequestering surplus. Both host and microbial systems have evolved elaborate me…
Host defenses8 sources
Metal-Dependent Virulence
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Host defenses12 sources
Metal-Driven Inflammation
Inflammation is a broad concept, but in the metallomics context it has a specific character: heavy metals and pathogens activate overlapping inflammatory pathways, creating convergent pathology where distinguishing the metal contribution from the microbial contribution …
Host defenses13 sources
Microbial Metallomics
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
N
Host defenses11 sources
Nutritional Immunity (Metal Sequestration)
The strategy by which mammalian hosts withhold essential metals from invading pathogens to limit their growth. Well-established for iron and zinc; underexplored but potentially powerful for nickel.
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Host defenses6 sources
Reactive Oxygen Species (ROS)
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
S
Host defenses14 sources
Siderophores
Siderophores are small, high-affinity iron-chelating molecules secreted by bacteria, fungi, and some plants to scavenge ferric iron (Fe3+) from their environment. In the context of infection, siderophores are the molecular weapons pathogens deploy to break through nutri…