Host defenses6 sources
Reactive Oxygen Species (ROS)
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Search: “ROS”
Ranked matches across titles, topics, categories, and article introductions, filtered to defense.
15 records in this view
Host defenses12 sources
Antimicrobial Metals
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Host defenses3 sources
Autoimmunity
Autoimmunity occurs when the immune system attacks the body's own tissues. What has emerged over the past two decades is that the gut microbiome is not merely associated with autoimmune disease -- it is a mechanistic driver of immune tolerance breakdown. Metals add a se…
Host defenses4 sources
Cysteine
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Host defenses6 sources
Dyshomeostasis
The pathological disruption of normal metal homeostasis — the tightly regulated balance of essential trace elements (iron, zinc, copper, manganese, selenium, cobalt) and the effective exclusion of toxic metals (cadmium, lead, mercury, arsenic). Dyshomeostasis is a conve…
Host defenses10 sources
Glutathione (GSH)
The most abundant intracellular thiol and the master antioxidant of mammalian cells. Glutathione is a tripeptide (gamma-glutamyl-cysteinyl-glycine) whose sulfhydryl (-SH) group makes it both a critical antioxidant and a primary target for heavy metal binding. GSH deplet…
Host defenses6 sources
Hepcidin
The master regulator of systemic iron homeostasis. Hepcidin is a 25-amino-acid peptide hormone produced primarily by hepatocytes that controls iron absorption, recycling, and distribution by binding to and degrading ferroportin (SLC40A1/FPN) -- the only known cellular i…
Host defenses5 sources
IFN-gamma (Interferon Gamma)
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Host defenses6 sources
Innate Immunity
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Host defenses12 sources
Inter-Kingdom Metal Shielding
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Host defenses13 sources
Microbial Metallomics
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Host defenses8 sources
N-Acetylcysteine (NAC)
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Host defenses5 sources
Siderophore Competition
Small, high-affinity iron-chelating molecules secreted by bacteria and fungi to scavenge ferric iron (Fe3+) from the environment. Siderophore competition is a fundamental ecological force in the gut microbiome: organisms with superior iron acquisition systems gain a dec…
Host defenses14 sources
Siderophores
Siderophores are small, high-affinity iron-chelating molecules secreted by bacteria, fungi, and some plants to scavenge ferric iron (Fe3+) from their environment. In the context of infection, siderophores are the molecular weapons pathogens deploy to break through nutri…
Host defenses12 sources
Superoxide Dismutase
This knowledge-base record is being expanded from WikiBiome’s evidence graph.