Host defenses11 sources
Pathogen Metal Acquisition Systems
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Search: “pathogen”
Ranked matches across titles, topics, categories, and article introductions, filtered to defense.
11 records in this view
Host defenses4 sources
Calprotectin (S100A8/A9)
A heterodimer of S100A8 and S100A9 calcium-binding proteins that constitutes approximately 60% of the cytosolic protein content of neutrophils. Calprotectin is a central effector of nutritional immunity, sequestering essential transition metals from invading pathogens a…
Host defenses5 sources
IFN-gamma (Interferon Gamma)
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Host defenses5 sources
Lactoferrin
An iron-binding glycoprotein of the transferrin family that sequesters iron (and potentially other metals) from pathogens at mucosal surfaces and sites of inflammation. Lactoferrin is a key effector of nutritional immunity, complementing calprotectin's role in metal res…
Host defenses3 sources
Metal Homeostasis
The biological processes by which organisms maintain proper intracellular and systemic concentrations of essential metals -- importing what is needed, storing excess safely, and exporting or sequestering surplus. Both host and microbial systems have evolved elaborate me…
Host defenses8 sources
Metal-Dependent Virulence
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Host defenses12 sources
Metal-Driven Inflammation
Inflammation is a broad concept, but in the metallomics context it has a specific character: heavy metals and pathogens activate overlapping inflammatory pathways, creating convergent pathology where distinguishing the metal contribution from the microbial contribution …
Host defenses13 sources
Microbial Metallomics
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Host defenses11 sources
Nutritional Immunity (Metal Sequestration)
The strategy by which mammalian hosts withhold essential metals from invading pathogens to limit their growth. Well-established for iron and zinc; underexplored but potentially powerful for nickel.
Host defenses14 sources
Siderophores
Siderophores are small, high-affinity iron-chelating molecules secreted by bacteria, fungi, and some plants to scavenge ferric iron (Fe3+) from their environment. In the context of infection, siderophores are the molecular weapons pathogens deploy to break through nutri…
Host defenses12 sources
Superoxide Dismutase
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