Microbial Metallomics and Parkinson's Disease: A Unified Metal-Driven Framework Linking Ferroptosis, Dysbiosis, and alpha-Synuclein Pathology
Karen Pendergrass
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- Year
- 2025
- Journal
- Conference Presentation
- WikiBiome key
pendergrass-2026-microbial-metallomics-parkinsons-ferroptosis
This paper introduced the unified framework connecting microbial metallomics, ferroptosis, and alpha-synuclein pathology in Parkinson's disease — three domains that had never been integrated. It provides the mechanistic explanation for why iron dysregulation in the gut drives both microbial dysbiosis and dopaminergic neurodegeneration through a single metal-dependent cascade. This framework is the structural basis for WikiBiome's Parkinson's disease signature and fundamentally reframed PD as a metallomics-driven ecological collapse rather than a purely neurological event.
Criteria met: 1 · 2 · 4 · 5Used in 24 visible records
microbeAkkermansia muciniphila→entityDopamine→microbeEnterobacteriaceae→microbeFaecalibacterium prausnitzii→metalIron→microbeLachnospiraceae (Family)→microbeLachnospiraceae→metalManganese→metalNickel→diseaseParkinson's Disease→microbePrevotella→microbePrevotellaceae→microbeRoseburia→metalSelenium→diseaseType 2 Diabetes→mechanismCurli Amyloid Fibers→mechanismDysbiosis→mechanismFenton Chemistry→defenseFerroportin→mechanismFerroptosis→defenseGlutathione (GSH)→mechanismGut-Brain Axis→mechanismGut-Metal-Microbiome Interactions→defenseHepcidin→Connect the evidence
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