Role of Nickel in Microbial Pathogenesis
Robert J. Maier, Stéphane L. Benoit
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- Year
- 2019
- Journal
- Inorganics
- WikiBiome key
maier-2019-nickel-microbial-pathogenesis
This paper established that nickel serves as an essential cofactor for virulence enzymes across more than 40 prokaryotic and 9 eukaryotic pathogens — and that mammals produce no known nickel-requiring proteins. That single asymmetry is the foundation of WikiBiome's metallomics thesis: nickel restriction could disable pathogen virulence without harming the host. Without this paper, WikiBiome could not explain why nickel contamination in agriculture selects for pathogenic organisms in the gut, a connection that underpins the metallomic layer of multiple disease signatures.
Criteria met: 1 · 2 · 4 · 5Used in 24 visible records
microbeBifidobacterium→microbeBrucella→microbeCampylobacter jejuni→microbeCampylobacter→microbeCandida albicans→diseaseCirrhosis→microbeClostridioides difficile→metalCobalt→microbeCryptococcus neoformans→microbeEscherichia coli→microbeEscherichia→diseaseGastric Adenocarcinoma→diseaseGastric Ulcer→microbeHelicobacter hepaticus→microbeHelicobacter pylori→microbeKlebsiella pneumoniae→microbeKlebsiella→microbeMycobacterium tuberculosis→otherNeisseria Meningitidis→metalNickel→microbeProteus mirabilis→microbeProteus→microbePseudomonas aeruginosa→microbeSalmonella enterica serovar Typhimurium→Connect the evidence
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