WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions.
Microbial tryptophan metabolites produced by gut bacteria through the third branch of tryptophan metabolism -- the indole pathway. Unlike the host-dominated kynurenine pathway (~95% of Trp) and the serotonin pathway (~1-2%), the indole pathway is exclusively microbial a…
Ketone bodies (beta-hydroxybutyrate [BHB], acetoacetate, acetone) are produced by hepatic fatty acid oxidation during carbohydrate restriction, fasting, or ketogenic diet consumption. BHB is the most abundant and is structurally and functionally analogous to butyrate — …
The kynurenine pathway (KP) is the dominant route of tryptophan catabolism, accounting for approximately 95% of dietary tryptophan degradation. It produces a cascade of neuroactive, immunomodulatory, and potentially neurotoxic metabolites whose balance determines whethe…
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Polyphenols are a diverse class of plant-derived compounds characterized by multiple phenol structural units. They are among the most abundant antioxidants in the human diet, found in fruits, vegetables, tea, coffee, wine, chocolate, and spices. What makes polyphenols p…
A filamentous fungus in the order Hypocreales (family Ophiocordycipitaceae), historically studied as an insect and nematode pathogen (P. lilacinum, formerly Paecilomyces lilacinus), now emerging as a clinically significant protective member of the gut mycobiome — and it…
Taurine (2-aminoethanesulfonic acid) is a sulfur-containing amino acid abundant in bile, heart, brain, and retina. Its primary metabolic role is bile acid conjugation — taurocholate and taurochenodeoxycholate are the taurine-conjugated primary bile acids that BSH-produc…