Mechanisms5 sources
Arachidonic Acid
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Search: “fatty-acid”
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Mechanisms3 sources
Butyrate
The most biologically potent short-chain fatty acid (C4). Butyrate is the primary energy source for colonocytes, a histone deacetylase (HDAC) inhibitor with broad epigenetic effects, and a key anti-inflammatory mediator. Its depletion -- driven by loss of butyrate-produ…
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Mechanisms8 sources
Gut Microbiome
The community of trillions of microorganisms — bacteria, archaea, fungi (mycobiome), viruses, and bacteriophages — inhabiting the human gastrointestinal tract, with the highest density in the colon (~10¹¹ cells/g). The gut microbiome encodes 100–150 times more genes tha…
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Mechanisms6 sources
Lipid Metabolism
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Mechanisms7 sources
Metabolomics
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Mechanisms10 sources
Mitochondrial Dysfunction
Mitochondrial dysfunction refers to the impairment of mitochondrial energy production, redox balance, and signaling functions. Mitochondria are the primary targets of heavy metal toxicity in human cells, and they are also the organelles most dependent on metal cofactors…