Arachidonic Acid

Microbiome Connection#

COX-2/NF-kB axis: Metal-driven NF-kB activation upregulates COX-2, increasing arachidonic acid conversion to pro-inflammatory prostaglandin E2 (PGE2)—the same pathway activated by microbial LPS via TLR4.^{[1]Nonsteroidal Anti-Inflammatory Drugs as Therapeutic Allies of the Gut Microbiome on Chronic InflammationFabian Mermans, Evelien Heiremans, Maud Van Belleghem et al. · 2019Open reference 1 ↓}

NSAIDs and microbiome: NSAIDs (COX inhibitors blocking AA metabolism) cause Gut Microbiome disruption and intestinal injury, paradoxically increasing Dysbiosis while reducing Metal-Driven Inflammation.^{[1]Nonsteroidal Anti-Inflammatory Drugs as Therapeutic Allies of the Gut Microbiome on Chronic InflammationFabian Mermans, Evelien Heiremans, Maud Van Belleghem et al. · 2019Open reference 1 ↓}

Endometriosis metabolomics: Altered arachidonic acid levels in fecal metabolomics of endometriosis models.^{[2]Ni 2020 — Fecal Metabolomics and Gut Microbiota Correlation in Endometriosis MiceZhexin Ni, Shuai Sun, Yanli Bi et al. · 2020Open reference 2 ↓} Diabetic ED: Fatty acid profiles including AA altered in diabetic erectile dysfunction.^{[3]Ben Khedher 2017 — Disturbed Fatty Acids Metabolism in Diabetic Erectile DysfunctionMohamed Raâfet Ben Khedher, Houda Bouhajja, Samia Haj Ahmed et al. · 2017Open reference 3 ↓}