Associations of Environmental Exposure to Arsenic, Manganese, Lead, and Cadmium with Alzheimer's Disease: A Review of Recent Evidence from Mechanistic Studies

Giasuddin Ahmed, Md. Shiblur Rahaman, Enrique Perez, Khalid M. Khan

Share & cite

Article toolsAssociations of Environmental Exposure to Arsenic, Manganese, Lead, and Cadmium with Alzheimer's Disease: A Review of Recent Evidence from Mechanistic Studies

Links open in a new tab.

Citation record

Year: 2025
Journal: Journal of Xenobiotics
DOI: 10.3390/jox15020047 ↗
WikiBiome key: ahmed-2025-metals-alzheimers-mechanistic-review

Why this source matters

Comprehensively maps metal-specific mechanisms (arsenic: tau phosphorylation via GSK3-beta/ERK; manganese: autophagy impairment; lead/cadmium: blood-brain barrier disruption) converging on Alzheimer's disease pathology across 45 mechanistic studies. WikiBiome depends on this evidence to explain how distinct metal burdens select for divergent neurodegenerative trajectories—establishing metal-specific toxicology as deterministic of proteinopathy type rather than a generic oxidative insult.

Criteria met: 2 · 3 · 4

Used in 18 visible records

diseaseAlzheimer's Disease→metalCalcium→metalLead→metalManganese→metalNickel→diseaseParkinson's Disease→mechanismAmyloid-Beta Aggregation→mechanismAmyloid-Beta→mechanismAutophagy→defenseDyshomeostasis→mechanismImmune Balance→defenseMetal-Driven Inflammation→mechanismMicroglia→mechanismNeurodegeneration and Metals→mechanismNeuroinflammation→mechanismNF-kB Signaling Pathway→mechanismTau Phosphorylation→stopSTOP: Iron Supplementation for Alzheimer's Disease→

Author connection

Are you an author of this work?

Every coauthor may independently claim authorship through ORCID, check this record, add context, and see where the work is used.

Claim or review this work →

Researcher discussion

Connect the evidence

Publicly readable discussion by ORCID-authenticated researchers. Questions, interpretation, methods, corrections, and new evidence stay attached to this record.

0 posts

No discussion yet. Start with a precise question or a source-backed observation.

Transparent record

Published page changes

This record shows only material changes published on this page, including changes to its content, evidence, conclusions, or author context. Internal processes and discussion activity are excluded. Pending, declined, and withdrawn proposals remain private.

0 changes

No material page changes have been recorded yet.