WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions, filtered to mechanism.
Disruption of the normal composition and metabolic function of microbial communities, particularly the gut microbiome. In the metallomics context, dysbiosis is both a consequence of metal toxicity and an amplifier of further disease -- creating vicious cycles where meta…
The intestinal epithelium is a single-cell-thick barrier separating the lumen -- home to trillions of microbes and ingested metals -- from the systemic circulation. When this barrier fails, the consequences cascade: microbial products translocate, metals gain unrestrict…
The ability of certain metals to cause cancer has been known since the 19th century. The three metals covered in this wiki — nickel, arsenic, and chromium — represent distinct mechanistic paradigms that collectively illustrate the diversity of metal-induced carcinogenes…
TGF-beta is a pleiotropic cytokine with dual roles: immunosuppressive (driving regulatory T cell [Treg] differentiation and maintaining immune tolerance) and pro-fibrotic (promoting extracellular matrix deposition, wound healing, and tissue fibrosis). In the WikiBiome c…
Toll-like receptors (TLRs) are a family of pattern recognition receptors (PRRs) that form the front line of the innate immune system. They detect conserved molecular patterns from microbes -- pathogen-associated molecular patterns (PAMPs) -- and damage-associated molecu…