Lachnoclostridium

Lachnoclostridium is a genus of obligate anaerobic, Gram-positive bacteria in the lachnospiraceae family. It is a butyrate-producing commensal with emerging clinical significance as a treatment response biomarker and diagnostic marker.

Key Associations

  • Schizophrenia: Baseline Lachnoclostridium abundance predicts treatment response to risperidone — higher baseline = better 24-week outcome [1].
  • CRC: Enriched in early-stage CRC; proposed as diagnostic biomarker for early detection [2].
  • Hashimoto's: Altered in HT gut microbiota [3].
  • Male fertility: 3-HPP metabolite from Lachnoclostridium protects spermatogenesis against ferroptosis [4].

Cross-References

References (4)

  1. Yuan X, Wang Y, Li X et al. (2021). Gut Microbial Biomarkers for the Treatment Response in First-Episode, Drug-Naive Schizophrenia: A 24-Week Follow-Up Study. Translational Psychiatry. doi:10.1038/s41398-021-01531-3
  2. Wu Y, Jiao N, Zhu R et al. (2021). Identification of Microbial Markers across Populations in Early Detection of Colorectal Cancer. Nature Communications. doi:10.1038/s41467-021-23265-y
  3. Liu J, Qin X, Lin B et al. (2022). Analysis of gut microbiota diversity in Hashimoto's thyroiditis patients. BMC Microbiology. doi:10.1186/s12866-022-02739-z
  4. Zirun Jin, Yuzhuo Yang, Yalei Cao et al. (2023). Jin 2023 — Gut Metabolite 3-HPAA Rejuvenates Spermatogenic Dysfunction in Aged Mice through GPX4-Mediated Ferroptosis. Microbiome. doi:10.1186/s40168-023-01659-y

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