Lachnoclostridium is a genus of obligate anaerobic, Gram-positive bacteria in the Lachnospiraceae family. It is a Butyrate-producing commensal with emerging clinical significance as a treatment response biomarker and diagnostic marker.
Evidence map4 cited passagesInspect provenance +
Schizophrenia: Baseline Lachnoclostridium abundance predicts treatment response to risperidone—higher baseline = better 24-week outcome.
CRC: Enriched in early-stage CRC; proposed as diagnostic biomarker for early detection.
Hashimoto's: Altered in HT gut microbiota.
Male fertility: 3-HPP metabolite from Lachnoclostridium protects spermatogenesis against ferroptosis.
Key Associations#
Schizophrenia: Baseline Lachnoclostridium abundance predicts treatment response to risperidone—higher baseline = better 24-week outcome.[1]Gut Microbial Biomarkers for the Treatment Response in First-Episode, Drug-Naive Schizophrenia: A 24-Week Follow-Up StudyYuan X, Wang Y, Li X et al. · 2021Open reference 1 ↓
CRC: Enriched in early-stage CRC; proposed as diagnostic biomarker for early detection.[2]Identification of Microbial Markers across Populations in Early Detection of Colorectal CancerWu Y, Jiao N, Zhu R et al. · 2021Open reference 2 ↓ Hashimoto's: Altered in HT gut microbiota.[3]Analysis of gut microbiota diversity in Hashimoto's thyroiditis patientsLiu J, Qin X, Lin B et al. · 2022Open reference 3 ↓ Male fertility: 3-HPP metabolite from Lachnoclostridium protects spermatogenesis against ferroptosis.[4]Jin 2023 — Gut Metabolite 3-HPAA Rejuvenates Spermatogenic Dysfunction in Aged Mice through GPX4-Mediated FerroptosisZirun Jin, Yuzhuo Yang, Yalei Cao et al. · 2023Open reference 4 ↓
Cross-References#
- Lachnospiraceae—family context
- butyrate—primary metabolic output
- Schizophrenia—treatment response predictor
- Ferroptosis—3-HPP metabolite protects against testicular ferroptosis
References 4
Numbered by first appearance in the article, then reconciled with its declared source list.
- 1
Yuan X, Wang Y, Li X et al. (2021). Gut Microbial Biomarkers for the Treatment Response in First-Episode, Drug-Naive Schizophrenia: A 24-Week Follow-Up Study. Translational Psychiatry.
- 2
Wu Y, Jiao N, Zhu R et al. (2021). Identification of Microbial Markers across Populations in Early Detection of Colorectal Cancer. Nature Communications.
- 3
Liu J, Qin X, Lin B et al. (2022). Analysis of gut microbiota diversity in Hashimoto's thyroiditis patients. BMC Microbiology.
- 4
Zirun Jin, Yuzhuo Yang, Yalei Cao et al. (2023). Jin 2023 — Gut Metabolite 3-HPAA Rejuvenates Spermatogenic Dysfunction in Aged Mice through GPX4-Mediated Ferroptosis. Microbiome.
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