Lachnoclostridium is a genus of obligate anaerobic, Gram-positive bacteria in the lachnospiraceae family. It is a butyrate-producing commensal with emerging clinical significance as a treatment response biomarker and diagnostic marker.
Key Associations
- Schizophrenia: Baseline Lachnoclostridium abundance predicts treatment response to risperidone — higher baseline = better 24-week outcome yuan 2021 gut microbial biomarkers treatment response schizophrenia.
- CRC: Enriched in early-stage CRC; proposed as diagnostic biomarker for early detection wu 2021 microbial markers populations early crc.
- Hashimoto's: Altered in HT gut microbiota liu 2022 gut microbiota diversity hashimotos.
- Male fertility: 3-HPP metabolite from Lachnoclostridium protects spermatogenesis against ferroptosis jin 2023 3hpaa spermatogenesis ferroptosis.
Cross-References
- lachnospiraceae — family context
- butyrate — primary metabolic output
- schizophrenia — treatment response predictor
- ferroptosis — 3-HPP metabolite protects against testicular ferroptosis