Scholefield et al. 2024 — Brain Metallomic Signatures Distinguish DLB from AD and PDD
Melissa Scholefield, Stephanie J. Church, Jingshu Xu, Garth J. S. Cooper
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- Year
- 2024
- Journal
- Frontiers in Neuroscience
- WikiBiome key
scholefield-2024-brain-metallomics-dementia
Shows that brain metallomic signatures — the spatial distribution of Fe, Cu, Zn, Mn across specific regions — discriminate dementia with Lewy bodies from Alzheimer's and Parkinson's disease dementia. Establishes that neurodegenerative diseases are metallomically distinct phenotypes, not variants of a single cascade, and grounds WikiBiome's differential signatures for DLB, AD, and PDD.
Criteria met: 1 · 2 · 3 · 4 · 5Used in 19 visible records
diseaseAlzheimer's Disease→metalCalcium→metalCopper→metalIron→metalLead→metalManganese→diseaseParkinson's Disease→metalSelenium→metalZinc→mechanismAmyloid-Beta Aggregation→mechanismCeruloplasmin→mechanismCopper Dysregulation→mechanismFerroptosis→mechanismMetallomics→mechanismNeurodegeneration and Metals→stopSTOP: Iron Supplementation for Alzheimer's Disease→analysisDietary Metal Paradoxes: When Healthy Foods and Good Intentions Backfire→analysisMetal-Disease Matrix: A Cross-Source Synthesis→analysisThe Copper Everywhere-and-Nowhere Problem→Connect the evidence
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