Search: “UTI”

Ranked matches across titles, topics, categories, and article introductions, filtered to defense.

9 records in this view

Host defenses12 sources

Antimicrobial Metals

This knowledge-base record is being expanded from WikiBiome’s evidence graph.

Host defenses4 sources

A heterodimer of S100A8 and S100A9 calcium-binding proteins that constitutes approximately 60% of the cytosolic protein content of neutrophils. Calprotectin is a central effector of nutritional immunity, sequestering essential transition metals from invading pathogens a…

Host defenses6 sources

Dyshomeostasis

The pathological disruption of normal metal homeostasis — the tightly regulated balance of essential trace elements (iron, zinc, copper, manganese, selenium, cobalt) and the effective exclusion of toxic metals (cadmium, lead, mercury, arsenic). Dyshomeostasis is a conve…

Host defenses3 sources

Ferritin

The primary intracellular iron storage protein, capable of sequestering up to 4,500 iron atoms in a single molecule as a mineralized ferric oxyhydroxide core. Ferritin is one of the most elegant solutions evolution has produced for the iron paradox: iron is essential fo…

Host defenses6 sources

Hepcidin

The master regulator of systemic iron homeostasis. Hepcidin is a 25-amino-acid peptide hormone produced primarily by hepatocytes that controls iron absorption, recycling, and distribution by binding to and degrading ferroportin (SLC40A1/FPN) -- the only known cellular i…

Host defenses5 sources

Lactoferrin

An iron-binding glycoprotein of the transferrin family that sequesters iron (and potentially other metals) from pathogens at mucosal surfaces and sites of inflammation. Lactoferrin is a key effector of nutritional immunity, complementing calprotectin's role in metal res…

Host defenses12 sources

Metal-Driven Inflammation

Inflammation is a broad concept, but in the metallomics context it has a specific character: heavy metals and pathogens activate overlapping inflammatory pathways, creating convergent pathology where distinguishing the metal contribution from the microbial contribution …

Host defenses11 sources

Nutritional Immunity (Metal Sequestration)

The strategy by which mammalian hosts withhold essential metals from invading pathogens to limit their growth. Well-established for iron and zinc; underexplored but potentially powerful for nickel.

Host defenses14 sources

Siderophores

Siderophores are small, high-affinity iron-chelating molecules secreted by bacteria, fungi, and some plants to scavenge ferric iron (Fe3+) from their environment. In the context of infection, siderophores are the molecular weapons pathogens deploy to break through nutri…