Lactobacillus Gasseri

Lactobacillus gasseri is a vaginal and gut commensal that defines Community State Type II (CST-II) in the vaginal microbiome. It is a common probiotic species with anti-obesity properties in clinical trials.

Vaginal Ecology

  • Dominates CST-II vaginal microbiomes — less protective than L. crispatus (CST-I) but more protective than L. iners (CST-III).
  • Part of vaginal microbiome shifts in endometriosis [1] [2].
  • Preterm birth associations [3].
  • Ovarian cancer microbiome context [4].

Clinical Evidence

  • Schizophrenia: Component of synbiotic for metabolic syndrome in schizophrenia RCT [5].
  • FMT: Component of reproductive tract FMT protocols [6].

Cross-References

References (6)

  1. Uzuner C, Mak J, El-Assaad F et al. (2023). The bidirectional relationship between endometriosis and microbiome. Frontiers in Endocrinology. doi:10.3389/fendo.2023.1110824
  2. John MacSharry, Zsuzsanna Kovacs, Yongjing Xie et al. (2024). MacSharry 2024 — Endometriosis Specific Vaginal Microbiota Links to Urine and Serum N-Glycome. Scientific Reports. doi:10.1038/s41598-024-76125-2
  3. Pamela Pruski, Gonçalo D. S. Correia, Holly V. Lewis et al. (2021). Pruski & Correia 2021 — Direct On-Swab Metabolic Profiling of Vaginal Microbiome Host Interactions During Pregnancy and Preterm Birth. Nature Communications. doi:10.1038/s41467-021-26215-w
  4. Asangba AE, Chen J, Goergen KM et al. (2023). Asangba 2023 — Diagnostic and prognostic potential of the microbiome in ovarian cancer treatment response. Scientific Reports. doi:10.1038/s41598-023-27555-x
  5. Basafa-Roodi P, Jazayeri S, Hadi F et al. (2024). Effects of Synbiotic Supplementation on the Components of Metabolic Syndrome in Patients with Schizophrenia: A Randomized, Double-Blind, Placebo-Controlled Trial. BMC Psychiatry. doi:10.1186/s12888-024-06061-y
  6. Georgina Quaranta, Mauro Pittiruti, Brunella Posteraro et al. (2019). Quaranta 2019 — FMT as a Potential Tool for Female Reproductive Tract Diseases (Review). Frontiers in Immunology. doi:10.3389/fimmu.2019.02653

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