Lactobacillus acidophilus is one of the most widely used probiotic species, with clinical trial evidence spanning multiple conditions. It is a component of many multi-strain probiotic formulations and has been tested in RCTs for schizophrenia, breast cancer chemotherapy support, CKD, and hypothyroidism.
Clinical Evidence
Schizophrenia: Part of multi-strain probiotic (with L. reuteri) + vitamin D that improved metabolic parameters in schizophrenia RCT [1].
Hypothyroidism: Synbiotic containing L. acidophilus improved thyroid parameters in hypothyroidism RCT [2].
Breast cancer: Probiotic support during chemotherapy; reviewed for breast cancer treatment [3][4].
CKD: Part of probiotic combination pilot for CKD [5].
Reproductive health: Component of FMT protocols for reproductive tract diseases [6].
Ghaderi A, Banafshe HR, Mirhosseini N et al. (2019). Clinical and Metabolic Response to Vitamin D Plus Probiotic in Schizophrenia Patients. BMC Psychiatry. doi:10.1186/s12888-019-2059-x
Ramezani M, Reisian M, Sajadi Hezaveh Z (2023). The Effect of Synbiotic Supplementation on Hypothyroidism: A Randomized Double-Blind Placebo Controlled Clinical Trial. PLoS ONE. doi:10.1371/journal.pone.0277213
Khazaei Y, Basi A, Fernandez ML et al. (2023). The effects of synbiotics supplementation on reducing chemotherapy-induced side effects in women with breast cancer. BMC Complementary Medicine and Therapies. doi:10.1186/s12906-023-04165-8
Mendoza L (2019). Potential effect of probiotics in the treatment of breast cancer. Oncology Reviews. doi:10.4081/oncol.2019.422
I-Kuan Wang, Tzung-Hai Yen, Pei-Shan Hsieh et al. (2021). Wang et al. 2021 — Effect of a Probiotic Combination in an Experimental Mouse Model and Clinical Patients with CKD: A Pilot Study. Frontiers in Nutrition. doi:10.3389/fnut.2021.661794
Georgina Quaranta, Mauro Pittiruti, Brunella Posteraro et al. (2019). Quaranta 2019 — FMT as a Potential Tool for Female Reproductive Tract Diseases (Review). Frontiers in Immunology. doi:10.3389/fimmu.2019.02653