Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder
Tizabi Y, Bennani S, El Kouhen N, Getachew B, Aschner M
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- Year
- 2023
- Journal
- Biomolecules
- WikiBiome key
tizabi-2023-lead-gut-microbiota-asd
Links lead exposure to autism-spectrum gut dysbiosis via specific taxa shifts — Faecalibacterium depletion, Lactobacillus loss, Desulfovibrio enrichment — consistent with the broader ASD microbial signature. Anchors lead as a metal driver of the autism signature and contributes to the cross-condition pattern in which Pb recurs across neurodevelopmental and neurodegenerative conditions.
Criteria met: 1 · 2 · 3 · 4Used in 14 visible records
diseaseAutism Spectrum Disorder→metalCalcium→microbeCoprococcus→microbeFirmicutes (Bacillota)→metalLead→metalZinc→mechanismDevelopmental Metal Vulnerability: Critical Windows of Susceptibility→mechanismDysbiosis→mechanismGut-Brain Axis→mechanismGut-Metal-Microbiome Interactions→mechanismHeavy Metal Neurotoxicity→mechanismMetal Chelation Therapy→mechanismMicroglia→mechanismNeuroinflammation→Connect the evidence
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