Environmental pollutants as risk factors for neurodegenerative disorders: Alzheimer and Parkinson diseases
Chin-Chan M, Navarro-Yepes J, Quintanilla-Vega B
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- Year
- 2015
- Journal
- Frontiers in Cellular Neuroscience
- WikiBiome key
chin-chan-2015-environmental-pollutants-ad-pd
Maps the connection between metal exposure (lead, mercury, arsenic, manganese) and proteinopathy mechanisms (amyloid-beta aggregation, tau phosphorylation, alpha-synuclein) in Alzheimer's and Parkinson's disease, with critical emphasis on developmental epigenetic priming. WikiBiome depends on this framework to explain why metal burden during critical windows drives neurodegenerative disease across distinct proteinopathies—establishing lead and manganese as selective pressures that alter both neuroinflammation and protein misfolding cascades.
Criteria met: 2 · 3 · 4Used in 15 visible records
metalAluminum→diseaseAlzheimer's Disease→diseaseDepression→metalIron→metalManganese→metalMercury→diseaseParkinson's Disease→mechanismAutophagy→mechanismEpigenetics→mechanismThe Exposome→mechanismMicroglia→mechanismMitochondrial Dysfunction→mechanismNeurodegeneration and Metals→mechanismNeuroinflammation→mechanismTau Phosphorylation→Connect the evidence
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