WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions, filtered to mechanism.
Arachidonic acid (AA) is a 20-carbon omega-6 polyunsaturated fatty acid (20:4n-6) that serves as the primary substrate for prostaglandin and leukotriene synthesis via COX-2 and 5-LOX pathways. It is the dominant pro-inflammatory lipid mediator — and its balance with ant…
The gut-prostate axis describes the bidirectional communication between the gut microbiome and the prostate gland. Gut-derived microbial metabolites, inflammatory mediators, and immune signals influence prostatic health, while prostatic disease states alter systemic inf…
Interleukin-10 is the primary anti-inflammatory cytokine, produced by Treg cells, macrophages, dendritic cells, and B cells. It suppresses pro-inflammatory cytokine production (IL-6, TNF-alpha, IL-1β), inhibits antigen presentation, and maintains immune tolerance. IL-10…
Interleukin-1 beta (IL-1β) is a master pro-inflammatory cytokine and the primary product of the NLRP3 inflammasome. Unlike IL-6 and TNF-alpha (which are transcriptionally regulated by nf kappa b), IL-1β requires a two-step activation: (1) NF-kB-driven transcription of p…
The immune system is not a monolith but a dynamic equilibrium between pro-inflammatory effector responses (Th1, Th2, Th17) and anti-inflammatory regulatory responses (Treg, IL-10, TGF-beta). Metals and the microbiome are two of the most potent environmental modulators o…
Polyunsaturated fatty acids (PUFAs) are fatty acids with multiple double bonds, divided into omega-3 (EPA, DHA, ALA) and omega-6 (arachidonic acid, linoleic acid) families. The omega-6:omega-3 ratio determines inflammatory tone — Western diets (~15:1) favor pro-inflamma…
The semen microbiome refers to the microbial community inhabiting the male reproductive tract and seminal fluid. Core genera identified through shotgun metagenomic sequencing include Corynebacterium, Staphylococcus, Streptococcus, and Prevotella, though composition vari…
The Th17/Treg balance is the immunological equilibrium between pro-inflammatory T helper 17 (Th17) cells and anti-inflammatory regulatory T (Treg) cells. This balance is the master switch between immune tolerance and autoimmune/inflammatory pathology — and the gut micro…
Tumor necrosis factor alpha (TNF-alpha) is a master pro-inflammatory cytokine produced primarily by macrophages, along with dendritic cells, T cells, and adipocytes. With 483 mentions across 262 files, TNF-alpha is the most referenced inflammatory mediator in the WikiBi…