WikiBiomeThe human microbiome encyclopediaRanked matches across titles, topics, categories, and article introductions, filtered to mechanism.
Bile acids are cholesterol-derived amphipathic molecules synthesized in the liver, secreted into the duodenum, and extensively modified by gut bacteria. The host-microbe co-metabolism of bile acids creates a signaling network with profound effects on lipid metabolism, g…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
The collective ability of the resident gut microbiome to prevent colonization by exogenous pathogens and suppress expansion of resident pathobionts. Colonization resistance is not a property of any single organism but an emergent function of the whole microbial communit…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Bidirectional communication between the gut microbiota and the central nervous system, mediated by neural (vagus nerve, enteric nervous system), immune (cytokines, microglia), endocrine (HPA axis), and metabolic (SCFAs, neurotransmitter precursors, tryptophan metabolite…
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Small molecules produced, modified, or activated by gut microbiota that function as the primary chemical language between the microbiome and its host. These metabolites are not passive byproducts — they regulate gene expression, immune cell differentiation, gut barrier …
This knowledge-base record is being expanded from WikiBiome’s evidence graph.
Taurine (2-aminoethanesulfonic acid) is a sulfur-containing amino acid abundant in bile, heart, brain, and retina. Its primary metabolic role is bile acid conjugation — taurocholate and taurochenodeoxycholate are the taurine-conjugated primary bile acids that BSH-produc…
Ursodeoxycholic acid is a hydrophilic secondary bile acid used therapeutically for primary biliary cholangitis (PBC), gallstone dissolution, and cholestatic liver disease. It is also a microbial metabolite — gut bacteria (7α/β-hydroxysteroid dehydrogenases) convert chen…