Ureaplasma Urealyticum

See also: ureaplasma (genus page with full biology and metal dependency profile)

Ureaplasma urealyticum is one of two human-pathogenic Ureaplasma species (alongside U. parvum). Like all Ureaplasma, it depends on nickel-dependent urease for energy generation.

Key Associations

  • Chronic prostatitis: Detected in prostatic secretions of men with chronic prostatitis [1].
  • Male infertility: Associated with impaired sperm quality through ammonia-mediated toxicity [2].

Cross-References

  • ureaplasma — genus page with complete metal dependency and mechanism detail
  • nickel urease — the essential nickel-dependent enzyme

References (10)

  1. Vittorio Magri, Matteo Boltri, Tommaso Cai et al. (2018). Magri 2018 — Multidisciplinary Approach to Prostatitis. Archivio Italiano di Urologia e Andrologia. doi:10.4081/aiua.2018.4.227
  2. Magill RG, MacDonald SM (2023). Magill 2023 — Male Infertility and the Human Microbiome. Frontiers in Reproductive Health. doi:10.3389/frph.2023.1166201
  3. Ata B, Yildiz S, Turkgeldi E et al. (2019). The Endobiota Study: Comparison of Vaginal, Cervical and Gut Microbiota Between Women with Stage 3/4 Endometriosis and Healthy Controls. Scientific Reports. doi:10.1038/s41598-019-39700-6
  4. Hernandes C, Silveira P, Sereia AFR et al. (2020). Microbiome Profile of Deep Endometriosis Patients: Comparison of Vaginal Fluid, Endometrium and Lesion. Diagnostics. doi:10.3390/diagnostics10030163
  5. Camila Hernandes, Paola Silveira, Aline Fernanda Rodrigues Sereia et al. (2020). Hernandes 2020 — Microbiome Profile of Deep Endometriosis Patients: Comparison of Vaginal Fluid, Endometrium and Lesion. Diagnostics. doi:10.3390/diagnostics10030163
  6. ★Robert J. Maier, Stéphane L. Benoit (2019). Role of Nickel in Microbial Pathogenesis. Inorganics. doi:10.3390/inorganics7070080
  7. Filipe T. Lira Neto, Marina C. Viana, Federica Cariati et al. (2024). Neto 2024 — Effect of Environmental Factors on Seminal Microbiome and Impact on Sperm Quality. Frontiers in Endocrinology. doi:10.3389/fendo.2024.1348186
  8. Liping Shen, Wei Zhang, Yi Yuan et al. (2022). Shen 2022 — Vaginal Microecological Characteristics of Women in Different Physiological and Pathological Periods. Frontiers in Cellular and Infection Microbiology. doi:10.3389/fcimb.2022.959793
  9. Nerea Molina Morales (2023). Molina Morales 2023 — The Microbiome of the Male Reproductive Tract: Uncovering Its Composition and Origins. Doctoral Thesis, Universidad de Granada. doi: https://hdl.handle.net/10481/85100 (malformed — flagged for audit)
  10. John MacSharry, Zsuzsanna Kovacs, Yongjing Xie et al. (2024). MacSharry 2024 — Endometriosis Specific Vaginal Microbiota Links to Urine and Serum N-Glycome. Scientific Reports. doi:10.1038/s41598-024-76125-2

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